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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.60

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.601.000
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.753
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.747
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.665
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.655
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.622
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.610
4gtt7TQGeranylgeranyl transferase type-2 subunit beta2.5.1.600.606
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.558
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.523
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.484
2cekN8TAcetylcholinesterase3.1.1.70.474
3n19FNRXenobiotic reductase/0.467
4y0kNAPAntE/0.460
3n0hTOPDihydrofolate reductase1.5.1.30.459
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.456
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.456
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.456
4uugPXGBranched-chain amino acid aminotransferase, putative/0.454
1blzACVIsopenicillin N synthase1.21.3.10.452
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.451
3ghvGHCDihydrofolate reductase1.5.1.30.451
4bfvZVVPantothenate kinase2.7.1.330.451
1ry8RUTAldo-keto reductase family 1 member C3/0.450
2x6o2TCTetracycline repressor protein class D/0.449
4e0u0MVCyclic dipeptide N-prenyltransferase/0.449
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.448
2w3mFOLDihydrofolate reductase1.5.1.30.448
4dvq1CACytochrome P450 11B2, mitochondrial1.14.15.40.448
1oc1ASVIsopenicillin N synthase1.21.3.10.447
4y1bNAPAntE/0.447
2xveFADPutative flavin-containing monooxygenase/0.446
1ry0PG2Aldo-keto reductase family 1 member C3/0.445
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.445
3v94WYQPhosphodiesterase/0.445
3zhuTD8Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.445
2y6fM9FIsopenicillin N synthase1.21.3.10.444
4dbs0HVAldo-keto reductase family 1 member C3/0.444
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.443
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.443
2xytTC9Soluble acetylcholine receptor/0.443
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.443
3zkuHCVIsopenicillin N synthase1.21.3.10.443
4m6l21VDihydrofolate reductase1.5.1.30.442
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.441
2j83BATUlilysin3.4.240.441
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.441
3ghwGHWDihydrofolate reductase1.5.1.30.441
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.441
2lfoGCHFatty acid-binding protein, liver/0.440
4v2gITCTetracycline repressor protein class D/0.440