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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3gwlFADFAD-linked sulfhydryl oxidase1.8.3.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3gwlFADFAD-linked sulfhydryl oxidase1.8.3.21.000
1oqcFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.560
3tk0FADFAD-linked sulfhydryl oxidase ALR1.8.3.20.560
3u2lFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.548
3r7cFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.538
3u5sFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.522
3mbgFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.520
3u2mFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.515
4e0hFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.513
4e0iFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.510
1jr8FADFAD-linked sulfhydryl oxidase ERV21.8.3.20.502
4ldkFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.501
3w4yFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.500
2hj3FADFAD-linked sulfhydryl oxidase ERV1/0.493
3t59FADSulfhydryl oxidase 11.8.3.20.493
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.477
4hw219HInduced myeloid leukemia cell differentiation protein Mcl-1/0.477
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.474
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.474
3t58FADSulfhydryl oxidase 11.8.3.20.470
1rp4FADEndoplasmic oxidoreductin-11.8.40.467
2dr3ADPUPF0273 protein PH0284/0.466
2ykiYKIHeat shock protein HSP 90-alpha/0.466
1rq1FADEndoplasmic oxidoreductin-11.8.40.465
2c27ACOMycothiol acetyltransferase2.3.1.1890.465
4eftEFTHeat shock protein HSP 90-alpha/0.465
2ykeYKEHeat shock protein HSP 90-alpha/0.462
3eej53RUncharacterized protein/0.461
1uy8PU5Heat shock protein HSP 90-alpha/0.460
3opdHIEHeat shock protein 83/0.460
4bqg50QHeat shock protein HSP 90-alpha/0.458
2wpwACOOrf14/0.457
4m10ICDProstaglandin G/H synthase 21.14.99.10.457
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.456
2bxqIMNSerum albumin/0.455
2vbdV10Isopenicillin N synthase1.21.3.10.455
3m31FADEndoplasmic oxidoreductin-11.8.40.455
3h3sH15Collagen type IV alpha-3-binding protein/0.454
4g7gVFVLanosterol 14-alpha-demethylase/0.454
1blzACVIsopenicillin N synthase1.21.3.10.453
2bu9HFVIsopenicillin N synthase1.21.3.10.453
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.453
3dl9V2HVitamin D 25-hydroxylase/0.453
1bk0ACVIsopenicillin N synthase1.21.3.10.452
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.452
3mnrSD1Heat shock protein HSP 90-alpha/0.452
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
5ab6CAANonspecific lipid-transfer protein, putative/0.452
5hs1VORLanosterol 14-alpha demethylase/0.452
4iui1GQEstrogen receptor/0.451
4zs2FLUAlpha-ketoglutarate-dependent dioxygenase FTO/0.451
1uzwCDHIsopenicillin N synthase1.21.3.10.450
2bxmIMNSerum albumin/0.450
2g0gSP0Peroxisome proliferator-activated receptor gamma/0.450
3b9lAZZSerum albumin/0.450
4bbhNHWGlycylpeptide N-tetradecanoyltransferase/0.450
4dliIRGMitogen-activated protein kinase 14/0.450
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.450
2pvlP55Casein kinase II subunit alpha2.7.11.10.449
4em9TCEPeroxisome proliferator-activated receptor gamma/0.449
3pm0BHFCytochrome P450 1B1/0.448
2yee2ECHeat shock protein HSP 90-alpha/0.447
4la0198Serum albumin/0.447
2w98P1ZProstaglandin reductase 21.3.1.480.446
1xddAAYIntegrin alpha-L/0.445
3syiFADSulfide-quinone reductase/0.445
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.444
3dd125DGlycogen phosphorylase, liver form2.4.1.10.444
3vspEK8Peroxisome proliferator-activated receptor gamma/0.444
4jbtASDCytochrome P450 monooxygenase/0.444
4uyf73BBromodomain-containing protein 2/0.444
1qjfACSIsopenicillin N synthase1.21.3.10.443
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.443
2fwyH64Heat shock protein HSP 90-alpha/0.443
2vcmM11Isopenicillin N synthase1.21.3.10.443
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.443
1pd9CO4Dihydrofolate reductase1.5.1.30.442
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3zewSTUEphrin type-B receptor 42.7.10.10.442
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
1xuoLA1Integrin alpha-L/0.441
2pvjP44Casein kinase II subunit alpha2.7.11.10.441
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
1qiqACCIsopenicillin N synthase1.21.3.10.440
1suoCPZCytochrome P450 2B41.14.14.10.440
2xvv9DNSerum albumin/0.440
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.440
3fwgCAMCamphor 5-monooxygenase1.14.15.10.440
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.440
4ho6UTPGlucose-1-phosphate thymidylyltransferase/0.440