sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 1.000 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.578 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.526 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.504 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.488 | |
| 5aux | KMP | Death-associated protein kinase 1 | 2.7.11.1 | 0.483 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.481 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.477 | |
| 5av3 | KMP | Death-associated protein kinase 1 | 2.7.11.1 | 0.474 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.472 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.469 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.467 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.465 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.464 | |
| 5e92 | ANP | TGF-beta receptor type-2 | 2.7.11.30 | 0.462 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.461 | |
| 1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.459 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.458 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.457 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.455 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 3i4b | Z48 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.455 | |
| 4aqc | 88A | Tyrosine-protein kinase JAK2 | / | 0.454 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.453 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 4fg7 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.453 | |
| 4k11 | 0J9 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.453 | |
| 2rio | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.452 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.452 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 1zp9 | ATP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.451 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.451 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.447 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.446 | |
| 5auw | QUE | Death-associated protein kinase 1 | 2.7.11.1 | 0.446 | |
| 3fln | 3FN | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.445 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 1ppm | 0P1 | Penicillopepsin-1 | 3.4.23.20 | 0.444 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.444 | |
| 4ic7 | ANP | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.444 | |
| 5auu | LU2 | Death-associated protein kinase 1 | 2.7.11.1 | 0.444 | |
| 2bro | DF2 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 4aac | AAV | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.443 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.442 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.442 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.442 | |
| 2wec | PP5 | Penicillopepsin-1 | 3.4.23.20 | 0.442 | |
| 3eyh | IZA | Tyrosine-protein kinase JAK1 | / | 0.442 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.442 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.442 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.442 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 2avv | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.440 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.440 | |
| 4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.440 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 5av4 | GEN | Death-associated protein kinase 1 | 2.7.11.1 | 0.440 |