sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.685 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.680 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.680 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.677 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.674 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.672 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.670 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.669 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.668 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.668 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.667 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.662 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.652 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.627 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.618 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.618 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.617 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.612 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.606 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.606 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.603 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.601 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.597 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.597 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.515 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.514 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.498 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.496 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.495 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.491 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.489 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.489 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.488 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.486 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.482 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.478 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.475 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.474 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.471 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.469 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.468 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.468 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.467 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.466 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.461 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.460 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.459 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.458 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.457 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.455 | |
| 4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.455 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.451 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.450 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.449 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.448 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.448 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.446 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.446 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3eej | 53R | Uncharacterized protein | / | 0.445 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.445 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.443 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2y3r | TRK | TamL | / | 0.443 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.443 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 3zuy | TCH | Transporter | / | 0.443 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.442 | |
| 3iqf | E4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.441 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.440 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.440 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.440 |