sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ele | PLP | Aminotransferase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ele | PLP | Aminotransferase | / | 1.000 | |
| 4wlj | IK2 | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.503 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.471 | |
| 4je5 | PLP | Aromatic/aminoadipate aminotransferase 1 | 2.6.1.39 | 0.466 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.464 | |
| 4rkd | KET | Aminotransferase | / | 0.464 | |
| 3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.463 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.462 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.461 | |
| 4fl0 | PLP | Aminotransferase ALD1, chloroplastic | 2.6.1 | 0.459 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.457 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.456 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.455 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.455 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.454 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.448 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.448 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.448 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.447 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.446 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.445 | |
| 1je1 | GMP | Purine nucleoside phosphorylase | / | 0.444 | |
| 3jq7 | DX2 | Pteridine reductase, putative | / | 0.444 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.444 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.443 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 1wkh | PPE | [LysW]-aminoadipate semialdehyde transaminase | / | 0.442 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.441 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 4iah | 1DX | Alr2278 protein | / | 0.441 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1og4 | NAI | T-cell ecto-ADP-ribosyltransferase 2 | / | 0.440 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 |