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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.91.000
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.630
2jk6FADTrypanothione reductase/0.624
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.596
4dnaFADProbable glutathione reductase/0.593
1fecFADTrypanothione reductase1.8.1.120.577
1tytFADTrypanothione reductase1.8.1.120.571
2wbaFADTrypanothione reductase1.8.1.120.571
2wp5FADTrypanothione reductase/0.569
4la1FADThioredoxin glutathione reductase/0.569
4nevFADTrypanothione reductase/0.568
1typFADTrypanothione reductase1.8.1.120.567
1febFADTrypanothione reductase1.8.1.120.566
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.565
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.563
1gxfFADTrypanothione reductase1.8.1.120.548
4j57FADThioredoxin reductase 21.8.1.90.547
1gerFADGlutathione reductase1.8.1.70.543
2hqmFADGlutathione reductase1.8.1.70.539
2w0hFADTrypanothione reductase/0.535
3grsFADGlutathione reductase, mitochondrial1.8.1.70.520
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.517
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.506
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.505
1grgFADGlutathione reductase, mitochondrial1.8.1.70.503
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.496
2wowFADTrypanothione reductase/0.494
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.483
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.481
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.468
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.463
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.460
2v6oFADThioredoxin glutathione reductase/0.453
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.453
3ntaFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.448
5er0FADUncharacterized NAD(FAD)-dependent dehydrogenase/0.444
3ntdFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.441
1bzlFADTrypanothione reductase1.8.1.120.440