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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3dleGFAGag-Pol polyprotein2.7.7.49

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3dleGFAGag-Pol polyprotein2.7.7.491.000
1klmSPPGag-Pol polyprotein2.7.7.490.626
1c1bGCAGag-Pol polyprotein2.7.7.490.622
1s1vTNKGag-Pol polyprotein2.7.7.490.622
3dmjGWEPol protein/0.617
3ffi3OBGag-Pol polyprotein2.7.7.490.614
4i7fNVEGag-Pol polyprotein2.7.7.490.598
3irxUDRGag-Pol polyprotein2.7.7.490.596
3is9AC7Gag-Pol polyprotein2.7.7.490.594
1rt2TNKGag-Pol polyprotein2.7.7.490.587
3t1a5MAGag-Pol polyprotein2.7.7.490.582
1jlaTNKGag-Pol polyprotein2.7.7.490.578
3i0rRT3Gag-Pol polyprotein2.7.7.490.573
3dokGWJPol protein/0.571
1rt1MKCGag-Pol polyprotein2.7.7.490.568
3dyaPZLGag-Pol polyprotein2.7.7.490.566
3i0sRT7Gag-Pol polyprotein2.7.7.490.565
3c6tM14Gag-Pol polyprotein2.7.7.490.554
3di6PDZGag-Pol polyprotein2.7.7.490.547
3lanKBTGag-Pol polyprotein2.7.7.490.547
3nbpJGZGag-Pol polyprotein2.7.7.490.547
3dolGWIPol protein/0.546
1tvrTB9Gag-Pol polyprotein2.7.7.490.545
2be2R22Gag-Pol polyprotein2.7.7.490.541
3lamKRPGag-Pol polyprotein2.7.7.490.541
3c6uM22Gag-Pol polyprotein2.7.7.490.539
3dlgGWEGag-Pol polyprotein2.7.7.490.535
2rkiTT1Gag-Pol polyprotein2.7.7.490.534
4rw4494Gag-Pol polyprotein2.7.7.490.531
3m8qDJZGag-Pol polyprotein2.7.7.490.526
1c1c612Gag-Pol polyprotein2.7.7.490.523
2ze2T27Gag-Pol polyprotein2.7.7.490.523
3lakKR1Gag-Pol polyprotein2.7.7.490.523
3t195MAGag-Pol polyprotein2.7.7.490.521
1tl3H20Gag-Pol polyprotein2.7.7.490.514
3drpR8EGag-Pol polyprotein2.7.7.490.514
3drrR8EGag-Pol polyprotein2.7.7.490.513
3e01PZ2Gag-Pol polyprotein2.7.7.490.510
3tamM06Gag-Pol polyprotein2.7.7.490.510
1rt5UC2Gag-Pol polyprotein2.7.7.490.509
2ynhEURGag-Pol polyprotein2.7.7.490.509
1hquHBYGag-Pol polyprotein2.7.7.490.501
1rtiHEFGag-Pol polyprotein2.7.7.490.501
1ep4S11Gag-Pol polyprotein2.7.7.490.495
2ic3HBYGag-Pol polyprotein2.7.7.490.492
1revTB9Gag-Pol polyprotein2.7.7.490.491
1rt7UC4Gag-Pol polyprotein2.7.7.490.491
1tktH12Gag-Pol polyprotein2.7.7.490.491
1ikyMSDGag-Pol polyprotein2.7.7.490.490
1hpzAAPGag-Pol polyprotein2.7.7.490.487
5cyqT27Gag-Pol polyprotein2.7.7.490.486
1s9eADBGag-Pol polyprotein2.7.7.490.483
4ko0JLJGag-Pol polyprotein2.7.7.490.480
1eetBFUGag-Pol polyprotein2.7.7.490.478
4ig3T27Gag-Pol polyprotein2.7.7.490.476
4kko1REGag-Pol polyprotein2.7.7.490.476
4i2q1BTGag-Pol polyprotein2.7.7.490.474
1hnvTBOGag-Pol polyprotein2.7.7.490.471
1hniAAAGag-Pol polyprotein2.7.7.490.470
1tkzH16Gag-Pol polyprotein2.7.7.490.470
1rt4UC1Gag-Pol polyprotein2.7.7.490.469
1vruAAPGag-Pol polyprotein2.7.7.490.460
1ikwEFZGag-Pol polyprotein2.7.7.490.458
2ban357Gag-Pol polyprotein2.7.7.490.457
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.457
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.457
1xzqFONtRNA modification GTPase MnmE3.6.50.456
2ynfWHUGag-Pol polyprotein2.7.7.490.456
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.456
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.455
1s1tUC1Gag-Pol polyprotein2.7.7.490.452
4wa9AXITyrosine-protein kinase ABL12.7.10.20.452
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.451
2vg7NNIGag-Pol polyprotein2.7.7.490.451
3jynNDPQuinone oxidoreductase/0.451
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.451
2w98P1ZProstaglandin reductase 21.3.1.480.450
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
3vev0H4Glucokinase2.7.1.20.447
1fk9EFZGag-Pol polyprotein2.7.7.490.446
1s6qTPBGag-Pol polyprotein2.7.7.490.446
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.446
4xldBRLPeroxisome proliferator-activated receptor gamma/0.445
1aq1STUCyclin-dependent kinase 22.7.11.220.444
1lwlDSOCamphor 5-monooxygenase1.14.15.10.444
2ebaFADPutative glutaryl-CoA dehydrogenase/0.444
3drcMTXDihydrofolate reductase1.5.1.30.442
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.441
2zjwREFCasein kinase II subunit alpha2.7.11.10.441
3gc8B45Mitogen-activated protein kinase 112.7.11.240.441
1re9DSOCamphor 5-monooxygenase1.14.15.10.440
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3mec65BGag-Pol polyprotein2.7.7.490.440
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.440