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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3dagFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3dagFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.21.000
3dafFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.700
3f46I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.689
3h65I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.646
3f47I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.605
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.466
4ocvANPAminoglycoside phosphotransferase/0.465
2vojNADAlanine dehydrogenase1.4.1.10.463
1u28NADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.460
1ptjSNDNAD(P) transhydrogenase subunit alpha part 11.6.1.20.457
4iarERM5-hydroxytryptamine receptor 1B/0.453
2zb3NDPProstaglandin reductase 21.3.1.480.450
2oorNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.448
3gw9VNILanosterol 14-alpha-demethylase/0.448
4a6bQG8Gag-Pol polyprotein3.4.23.160.448
4g3jVNTLanosterol 14-alpha-demethylase/0.448
2oo5TXDNAD(P) transhydrogenase subunit alpha part 11.6.1.20.447
4dfg0JVGag-Pol polyprotein3.4.23.160.445
1yb5NAPQuinone oxidoreductase1.6.5.50.442
3oxv478Gag-Pol polyprotein3.4.23.160.440