scPDB - Distribution of Binding site Similarity values of 3cse entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3cse	N22	Uncharacterized protein

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3cse	N22	Uncharacterized protein	/	1.000
3eek	53S	Uncharacterized protein	/	0.712
4h98	14Q	Uncharacterized protein	/	0.711
3qlz	QLZ	Uncharacterized protein	/	0.660
3qlx	QLR	Uncharacterized protein	/	0.615
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.607
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.606
3eej	53R	Uncharacterized protein	/	0.604
3eel	53T	Uncharacterized protein	/	0.602
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.585
3eem	53V	Uncharacterized protein	/	0.583
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.580
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.577
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.573
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.570
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.568
3qly	55V	Uncharacterized protein	/	0.566
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.557
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.557
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.557
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.556
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.550
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.547
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.545
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.544
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.542
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.542
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.541
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.539
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.534
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.533
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.524
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.523
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.522
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.522
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.520
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.519
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.518
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.518
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.517
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.516
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.515
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.515
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.515
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.514
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.514
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.513
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.512
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.512
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.512
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.509
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.502
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.502
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.498
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.497
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.496
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.493
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.493
2w3v	TOP	Dihydrofolate reductase	/	0.493
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.492
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.491
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.490
3ia4	MTX	Dihydrofolate reductase	/	0.487
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.487
3sa2	7DR	Dihydrofolate reductase	/	0.486
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.485
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.484
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.484
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.482
3sa1	6DR	Dihydrofolate reductase	/	0.482
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.482
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.481
3jwm	5WB	Dihydrofolate reductase	/	0.480
2zza	FOL	Dihydrofolate reductase	/	0.477
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.476
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.475
1qkn	RAL	Estrogen receptor beta	/	0.473
3jwc	EKB	Dihydrofolate reductase	/	0.473
3sai	9DR	Dihydrofolate reductase	/	0.473
3tq9	MTX	Dihydrofolate reductase	/	0.473
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.470
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.469
1kzj	CB3	Thymidylate synthase	/	0.466
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.466
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.465
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.464
1ia1	TQ3	Dihydrofolate reductase	1.5.1.3	0.464
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.464
3sh2	5DR	Dihydrofolate reductase	1.5.1.3	0.464
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.463
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.463
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.463
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.461
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.460
1m13	HYF	Nuclear receptor subfamily 1 group I member 2	/	0.459
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.458
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.457
3tqb	FOL	Dihydrofolate reductase	/	0.457
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.456
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.456
1x8l	OXR	Retinol dehydratase	/	0.455
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.455
2w3w	VG9	Dihydrofolate reductase	/	0.454
3dg8	RJ6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
3fra	I2H	Dihydrofolate reductase	1.5.1.3	0.454
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.454
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.454
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.452
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.452
3jw5	TOP	Dihydrofolate reductase	/	0.452
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.451
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.451
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.450
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.450
4elg	52J	Dihydrofolate reductase	/	0.450
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.450
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.449
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.449
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.449
3i8a	N22	Dihydrofolate reductase	1.5.1.3	0.449
4ele	31I	Dihydrofolate reductase	/	0.449
1dyr	TOP	Dihydrofolate reductase	1.5.1.3	0.448
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.448
3ezp	B3N	Histone deacetylase 8	3.5.1.98	0.448
4ejh	0QA	Cytochrome P450 2A13	1.14.14.1	0.447
4hw3	19G	Induced myeloid leukemia cell differentiation protein Mcl-1	/	0.446
1dhi	MTX	Dihydrofolate reductase	1.5.1.3	0.444
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.444
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.444
3irx	UDR	Gag-Pol polyprotein	2.7.7.49	0.444
4fjz	4FJ	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.444
3nxy	D2H	Dihydrofolate reductase	1.5.1.3	0.443
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.443
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.443
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.443
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.443
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.442
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.442
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.441
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.441
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.441
3sgv	2BJ	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.441
3fbu	COA	Acetyltransferase, GNAT family	/	0.440
3h1j	SMA	Cytochrome b	/	0.440
3s79	ASD	Aromatase	1.14.14.14	0.440