sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 1.000 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.836 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.653 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.641 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.556 | |
| 1lbb | KAI | Glutamate receptor 2 | / | 0.543 | |
| 1fw0 | KAI | Glutamate receptor 2 | / | 0.525 | |
| 4h8i | 11W | Glutamate receptor ionotropic, kainate 2 | / | 0.515 | |
| 3tza | TZG | Glutamate receptor 2 | / | 0.509 | |
| 4f3g | KAI | Glutamate receptor 3 | / | 0.508 | |
| 4dld | TZG | Glutamate receptor ionotropic, kainate 1 | / | 0.501 | |
| 4bdo | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.496 | |
| 4bdr | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.496 | |
| 2wky | IBC | Glutamate receptor ionotropic, kainate 1 | / | 0.492 | |
| 1ftl | DNQ | Glutamate receptor 2 | / | 0.490 | |
| 2xxv | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.489 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.480 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 2xxy | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.463 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.462 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 4f31 | KAI | Glutamate receptor 3 | / | 0.461 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.460 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 2y88 | 2ER | Phosphoribosyl isomerase A | 5.3.1.16 | 0.458 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.457 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.456 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.456 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.455 | |
| 2cwf | NDP | Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase | / | 0.453 | |
| 4wbd | ADP | Putative cysteine ligase BshC | / | 0.452 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.447 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.446 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.445 | |
| 3h03 | UBP | Glutamate receptor 2 | / | 0.443 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.443 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.442 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.442 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.440 | |
| 2b82 | ADN | Class B acid phosphatase | 3.1.3.2 | 0.440 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.440 | |
| 4lrr | CF9 | Thymidylate synthase | / | 0.440 | |
| 4req | 5AD | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.440 |