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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3b2eADPATPase GET3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3b2eADPATPase GET3/1.000
3gw9VNILanosterol 14-alpha-demethylase/0.462
3otxAP5Adenosine kinase, putative/0.458
4xiwAZMCarbonic anhydrase, alpha type/0.458
2oapANPType II secretion system protein (GspE-2)/0.454
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.453
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.452
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.450
3kb1ADPIron-sulfur cluster carrier protein/0.450
2jcxNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.448
3gobHXXDdmC/0.447
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
3b70NAPEnoyl reductase LovC10.445
3tjzGNPADP-ribosylation factor 1/0.445
1culFOKAdenylate cyclase type 2/0.444
1culFOKAdenylate cyclase type 5/0.444
1xe55FEPlasmepsin-23.4.23.390.444
4g7gVFVLanosterol 14-alpha-demethylase/0.444
2uxoTACHTH-type transcriptional regulator TtgR/0.443
3gwfNAPCyclohexanone monooxygenase/0.443
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
2vhtATPNTPase P4/0.442
2gjlFMNNitronate monooxygenase1.13.12.160.441
4i6gFADCryptochrome-2/0.441
4eb5PLPCysteine desulfurase IscS 2/0.440