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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3asjXYNHomoisocitrate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3asjXYNHomoisocitrate dehydrogenase/1.000
3asjXYMHomoisocitrate dehydrogenase/0.550
4xjxATPType I restriction enzyme EcoR124II R protein3.1.21.30.468
1gzfNADMono-ADP-ribosyltransferase C32.4.20.465
1u3cFADCryptochrome-1/0.463
3sptUD1Bifunctional protein GlmU/0.463
5aqzSGVHeat shock 70 kDa protein 1A/0.462
1u3dFADCryptochrome-1/0.458
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
1h47C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.451
1jvdUD1UDP-N-acetylhexosamine pyrophosphorylase2.7.7.230.450
3iewCTP2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase/0.450
3ea0ATPATPase, ParA family/0.446
3ix9MTXDihydrofolate reductase1.5.1.30.446
3jukUPGUTP--glucose-1-phosphate uridylyltransferase/0.446
2yqjUD1UDP-N-acetylglucosamine pyrophosphorylase2.7.7.230.445
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.445
3e8xNAPBH1520 protein/0.444
1ytmATPPhosphoenolpyruvate carboxykinase (ATP)/0.443
3dj4UD1Bifunctional protein GlmU/0.443
3qw4U5POrotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative/0.442
3buzLARActin, alpha skeletal muscle/0.441
3tycXHPDihydropteroate synthase/0.440
4gy2LARActin, alpha skeletal muscle/0.440