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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2y48FADLysine-specific histone demethylase 1A1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2y48FADLysine-specific histone demethylase 1A11.000
2jb1FADL-amino acid oxidase/0.538
2yg6FADPutrescine oxidase/0.535
1tdkFADL-amino-acid oxidase1.4.3.20.529
4i58FADCyclohexylamine Oxidase/0.515
1reoFADL-amino-acid oxidase1.4.3.20.504
3nn6FB06-hydroxy-L-nicotine oxidase/0.504
1yy5FADPolyamine oxidase FMS1/0.500
2jb2FADL-amino acid oxidase/0.495
5g3sFDAFlavin-dependent L-tryptophan oxidase VioA/0.495
1tdoFADL-amino-acid oxidase1.4.3.20.493
3k7tFAD6-hydroxy-L-nicotine oxidase/0.487
5g3tFDAFlavin-dependent L-tryptophan oxidase VioA/0.474
3qj4FADRenalase/0.471
1f8rFADL-amino-acid oxidase1.4.3.20.470
2yr4FADPhenylalanine 2-monooxygenase precursor1.13.12.90.468
2fsvNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.467
2oorNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.467
5idwNAPShort-chain dehydrogenase/reductase SDR/0.466
3lshFADPyranose 2-oxidase/0.465
5kjfNAJAlcohol dehydrogenase E chain1.1.1.10.465
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.463
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.461
2b9wFADPutative aminooxidase/0.460
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.459
5br7FADUDP-galactopyranose mutase/0.458
1rjdSAMLeucine carboxyl methyltransferase 12.1.1.2330.456
3l8kADPDihydrolipoamide dehydrogenase (PdhD-3)/0.455
1ptjSNDNAD(P) transhydrogenase subunit alpha part 11.6.1.20.454
2ylxFADPhenylacetone monooxygenase1.14.13.920.454
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.454
4u8iFDAUDP-galactopyranose mutase/0.454
5kczNAJAlcohol dehydrogenase E chain1.1.1.10.452
5kcpNAJAlcohol dehydrogenase E chain1.1.1.10.451
1f3pFADFerredoxin reductase/0.449
5iqiGNPBifunctional AAC/APH2.3.10.449
5jscFADPutative acyl-CoA dehydrogenase/0.449
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.448
3k4cFADPyranose 2-oxidase/0.447
5cdtNAJAlcohol dehydrogenase E chain1.1.1.10.447
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.446
2ba9FADPutative aminooxidase/0.446
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.446
1ipeNDPTropinone reductase 21.1.1.2360.445
2g0bNLTLong-chain N-acyl amino acid synthase/0.445
2ylzFADPhenylacetone monooxygenase1.14.13.920.445
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.445
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.444
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.444
3o96IQORAC-alpha serine/threonine-protein kinase2.7.11.10.444
1l7eNAINAD(P) transhydrogenase subunit alpha part 11.6.1.20.443
4mo2FDAUDP-galactopyranose mutase/0.443
1x7gNAPPutative ketoacyl reductase1.3.10.442
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.442
3nf4FADAcyl-CoA dehydrogenase domain-containing protein/0.442
3s5wNAPL-ornithine N(5)-monooxygenase/0.442
3ljtLA3A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.441
2qfxNDPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.440
2v3aFADRubredoxin-NAD(+) reductase1.18.1.10.440
4gdcFADUDP-galactopyranose mutase/0.440
4y9lFADAcyl-CoA dehydrogenase family member 11/0.440