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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xrlDXTTetracycline repressor protein class D

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2xrlDXTTetracycline repressor protein class D/1.000
2o7oDXTTetracycline repressor protein class D/0.687
4d7mTDCTetracycline repressor protein class D/0.673
5fkmTDCTetracycline repressor protein class D/0.661
2xpvMIYTetracycline repressor protein class D/0.657
2tctCTCTetracycline repressor protein class D/0.645
4b3aTACTetracycline repressor protein class D/0.634
4auxXTCTetracycline repressor protein class D/0.625
2fj1CTCTetracycline repressor protein class D/0.623
2trtTACTetracycline repressor protein class D/0.623
2xpwOTCTetracycline repressor protein class D/0.620
1orkATCTetracycline repressor protein class D/0.600
2vkeTACTetracycline repressor protein class D/0.582
5fklTDCTetracycline repressor protein class D/0.568
2xpuTDCTetracycline repressor protein class D/0.558
2xb5I7TTetracycline repressor protein class D/0.555
4abzT1CTetracycline repressor protein class D/0.552
4v2gITCTetracycline repressor protein class D/0.545
2vprTDCTetracycline repressor protein class H/0.543
2vkvTDCTetracycline repressor protein class D/0.542
4b1rITCTetracycline repressor protein class D/0.538
5fknTDCTetracycline repressor protein class D/0.525
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.510
5fkoTDCTetracycline repressor protein class D/0.497
2x9dITCTetracycline repressor protein class D/0.489
2x6o2TCTetracycline repressor protein class D/0.472
3gw9VNILanosterol 14-alpha-demethylase/0.466
1w6hTITPlasmepsin-23.4.23.390.463
2ignFADPyranose 2-oxidase/0.460
3ge6FMNNitroreductase/0.460
1u28NADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.456
1jipKTN6-deoxyerythronolide B hydroxylase/0.452
2npaMMBPeroxisome proliferator-activated receptor alpha/0.450
2igoFADPyranose 2-oxidase/0.448
2wzwFMNNitroreductase NfnB/0.444
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.442
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.440
2q9fC3SCholesterol 24-hydroxylase/0.440
4nxuADPMitochondrial dynamics protein MID51/0.440