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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2x8gFADThioredoxin glutathione reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2x8gFADThioredoxin glutathione reductase/1.000
2x8hFADThioredoxin glutathione reductase/0.785
4b1bFADThioredoxin reductase1.8.1.90.529
1dncFADGlutathione reductase, mitochondrial1.8.1.70.528
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.90.525
4la1FADThioredoxin glutathione reductase/0.517
2tprFADTrypanothione reductase1.8.1.120.499
1fecFADTrypanothione reductase1.8.1.120.480
3lqfNADGalactitol dehydrogenase/0.479
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.457
3gw9VNILanosterol 14-alpha-demethylase/0.454
3gqvNAPEnoyl reductase LovC10.453
4ambDUDPutative glycosyl transferase/0.453
1ipeNDPTropinone reductase 21.1.1.2360.450
2ebaFADPutative glutaryl-CoA dehydrogenase/0.449
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.449
4g3jVNTLanosterol 14-alpha-demethylase/0.449
2y0mACOHistone acetyltransferase KAT8/0.448
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.446
4fn4NADShort chain dehydrogenase/0.446
1xe55FEPlasmepsin-23.4.23.390.445
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.445
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.444
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.444
3d91REMRenin3.4.23.150.442
1me6IVSPlasmepsin-23.4.23.390.440
2wbaFADTrypanothione reductase1.8.1.120.440
2zjmF1MBeta-secretase 13.4.23.460.440
4q73FADBifunctional protein PutA/0.440
5jlaNADPutative short-chain dehydrogenase/reductase/0.440