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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2vkvTDCTetracycline repressor protein class D

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2vkvTDCTetracycline repressor protein class D/1.000
2xpwOTCTetracycline repressor protein class D/0.633
2o7oDXTTetracycline repressor protein class D/0.631
4b3aTACTetracycline repressor protein class D/0.628
2trtTACTetracycline repressor protein class D/0.613
5fklTDCTetracycline repressor protein class D/0.607
5fkoTDCTetracycline repressor protein class D/0.604
4auxXTCTetracycline repressor protein class D/0.600
2xpvMIYTetracycline repressor protein class D/0.599
5fkmTDCTetracycline repressor protein class D/0.593
1orkATCTetracycline repressor protein class D/0.580
2xrlDXTTetracycline repressor protein class D/0.564
2tctCTCTetracycline repressor protein class D/0.558
4d7mTDCTetracycline repressor protein class D/0.557
4abzT1CTetracycline repressor protein class D/0.556
2xb5I7TTetracycline repressor protein class D/0.548
2fj1CTCTetracycline repressor protein class D/0.544
2vkeTACTetracycline repressor protein class D/0.541
2xpuTDCTetracycline repressor protein class D/0.534
2vprTDCTetracycline repressor protein class H/0.532
4v2gITCTetracycline repressor protein class D/0.482
4b1rITCTetracycline repressor protein class D/0.479
2iko7IGRenin3.4.23.150.469
5fknTDCTetracycline repressor protein class D/0.468
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.464
2zsaADPPantothenate kinase2.7.1.330.464
4hmvWUBPhenazine biosynthesis protein PhzG1.40.464
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.463
3keuATPPyridoxal kinase2.7.1.350.461
2oapANPType II secretion system protein (GspE-2)/0.460
3af1GDPPantothenate kinase2.7.1.330.456
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.450
1nhpFADNADH peroxidase1.11.1.10.449
2wq6FADRE11660p/0.449
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.449
1h73ANPHomoserine kinase2.7.1.390.447
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.447
4q71FADBifunctional protein PutA/0.447
1f8wFADNADH peroxidase1.11.1.10.444
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.444
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.442
2wb2FADRE11660p/0.442
4ipw1G7Mycocyclosin synthase1.14.21.90.441
4itmATPTetraacyldisaccharide 4'-kinase/0.441
3junAKDPhenazine biosynthesis protein A/B/0.440