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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2tscCB3Thymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2tscCB3Thymidylate synthase/1.000
1jutLYDThymidylate synthase/0.567
1kceCB3Thymidylate synthase/0.533
1aiqCB3Thymidylate synthase/0.528
1tduCB3Thymidylate synthase/0.524
1dnaCB3Thymidylate synthase/0.520
1kzjCB3Thymidylate synthase/0.519
2kceD16Thymidylate synthase/0.516
1kziTHGThymidylate synthase/0.512
1fwmCB3Thymidylate synthase/0.507
1nceCB3Thymidylate synthase/0.506
1zprCB3Thymidylate synthase/0.501
2bbqPFGThymidylate synthase/0.494
1axwMTXThymidylate synthase/0.488
1jtuLYBThymidylate synthase/0.482
3bhlTHGThymidylate synthase/0.482
3bgxMEFThymidylate synthase/0.481
1jtqLY3Thymidylate synthase/0.480
1f4fTP3Thymidylate synthase/0.479
1hvyD16Thymidylate synthase2.1.1.450.475
1dduCB3Thymidylate synthase/0.468
1bq1CB3Thymidylate synthase/0.464
1jujLYAThymidylate synthase2.1.1.450.463
1ju6LYAThymidylate synthase2.1.1.450.462
4gevCB3Thymidylate synthase/0.461
1f4gTP4Thymidylate synthase/0.460
4fogC2FThymidylate synthase ThyA/0.458
2ftoCB3Thymidylate synthase/0.454
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.453
4knzCB3Thymidylate synthase/0.452
4fqsLYAThymidylate synthase ThyA/0.446
1tysDHFThymidylate synthase/0.445
1an5CB3Thymidylate synthase/0.441