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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pu2DK2Beta-lactamase3.5.2.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pu2DK2Beta-lactamase3.5.2.61.000
2r9w23CBeta-lactamase3.5.2.60.605
2r9xWH6Beta-lactamase3.5.2.60.546
1xgjHTCBeta-lactamase3.5.2.60.510
1l2sSTCBeta-lactamase3.5.2.60.502
1xgiNSTBeta-lactamase3.5.2.60.502
4ambDUDPutative glycosyl transferase/0.469
2qjoNADBifunctional NMN adenylyltransferase/Nudix hydrolase2.7.7.10.458
1bim0QBRenin3.4.23.150.455
4a83DXCMajor pollen allergen Bet v 1-A/0.453
1g1aNADdTDP-glucose 4,6-dehydratase/0.450
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.449
2g1r3IGRenin3.4.23.150.448
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.448
2vkeTACTetracycline repressor protein class D/0.445
2x92X92Angiotensin-converting enzyme3.4.15.10.445
3lqfNADGalactitol dehydrogenase/0.444
1galFADGlucose oxidase1.1.3.40.443
3own3OWRenin3.4.23.150.443
3k5c0BIBeta-secretase 13.4.23.460.442
4bxk1IUAngiotensin-converting enzyme3.2.10.442
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3nl6ACPUncharacterized protein/0.441