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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pdu393Aldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pdu393Aldose reductase1.1.1.211.000
2pdfZSTAldose reductase1.1.1.210.684
2fz9ZSTAldose reductase1.1.1.210.613
2pdxZSTAldose reductase1.1.1.210.596
2hv5ZSTAldose reductase1.1.1.210.589
2fz8ZSTAldose reductase1.1.1.210.580
2dv0ZSTAldose reductase1.1.1.210.578
2pdq47DAldose reductase1.1.1.210.576
1t40ID5Aldose reductase1.1.1.210.568
2pdp393Aldose reductase1.1.1.210.567
4gca2X9Aldose reductase1.1.1.210.567
1ieiZESAldose reductase1.1.1.210.560
2pdmZSTAldose reductase1.1.1.210.559
3ld5LDTAldose reductase1.1.1.210.559
1z3n3NAAldose reductase1.1.1.210.552
3ghrLDTAldose reductase1.1.1.210.550
2i17LDTAldose reductase1.1.1.210.549
3ghuLDTAldose reductase1.1.1.210.543
3lqlLDTAldose reductase1.1.1.210.543
2iki388Aldose reductase1.1.1.210.542
3ghtLDTAldose reductase1.1.1.210.542
2pzn393Aldose reductase1.1.1.210.540
3lboLDTAldose reductase1.1.1.210.539
2i16LDTAldose reductase1.1.1.210.538
2pdh47DAldose reductase1.1.1.210.537
2pdj393Aldose reductase1.1.1.210.536
3ghsLDTAldose reductase1.1.1.210.536
3t423T4Aldose reductase1.1.1.210.535
3m4h388Aldose reductase1.1.1.210.532
3m64393Aldose reductase1.1.1.210.532
1t41ID5Aldose reductase1.1.1.210.531
2qxwLDTAldose reductase1.1.1.210.525
2pdiZSTAldose reductase1.1.1.210.524
3mb9ZSTAldose reductase1.1.1.210.523
1z8962PAldose reductase1.1.1.210.522
2hvnZSTAldose reductase1.1.1.210.521
2pdbZSTAldose reductase1.1.1.210.521
2hvoZSTAldose reductase1.1.1.210.520
3g5eQ74Aldose reductase1.1.1.210.519
2ikj393Aldose reductase1.1.1.210.518
2duxZSTAldose reductase1.1.1.210.515
2duzZSTAldose reductase1.1.1.210.515
2f2kTGGAldose reductase1.1.1.210.515
1us0LDTAldose reductase1.1.1.210.513
2pdn47DAldose reductase1.1.1.210.513
2pdyFIDAldose reductase1.1.1.210.511
3lz5LDTAldose reductase1.1.1.210.510
2pdg47DAldose reductase1.1.1.210.508
2fzdTOLAldose reductase1.1.1.210.502
4yu153NAldose reductase1.1.1.210.498
1pwlBFIAldose reductase1.1.1.210.497
2agtFIDAldose reductase1.1.1.210.495
2pdlTOLAldose reductase1.1.1.210.491
1zuaTOLAldo-keto reductase family 1 member B101.1.10.490
1frbZSTAldose reductase-related protein 2/0.488
2pdc393Aldose reductase1.1.1.210.488
3mc5393Aldose reductase1.1.1.210.483
2aovC2MHistamine N-methyltransferase2.1.1.80.480
2pd5ZSTAldose reductase1.1.1.210.476
4wevSUZAldo-keto reductase family 1 member B101.1.10.473
3lenZSTAldose reductase1.1.1.210.467
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.466
3u2cSUZAldose reductase1.1.1.210.465
2inzOHPAldose reductase1.1.1.210.464
2ikhLITAldose reductase1.1.1.210.462
1ekoI84Aldose reductase1.1.1.210.460
3m0iZSTAldose reductase1.1.1.210.458
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.458
3p2vDOYAldose reductase1.1.1.210.456
3s3gTLTAldose reductase1.1.1.210.456
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.455
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.455
2iqdLPAAldose reductase1.1.1.210.451
1ef3FIDAldose reductase1.1.1.210.450
2xufTZ4Acetylcholinesterase3.1.1.70.448
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.448
2pd9FIDAldose reductase1.1.1.210.447
1q23FUAChloramphenicol acetyltransferase2.3.1.280.445
4ga8SBIAldo-keto reductase family 1 member B101.1.10.445
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.444
1u65CP0Acetylcholinesterase3.1.1.70.443
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.442