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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pdiZSTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pdiZSTAldose reductase1.1.1.211.000
2fz8ZSTAldose reductase1.1.1.210.733
3ghtLDTAldose reductase1.1.1.210.674
3ghrLDTAldose reductase1.1.1.210.670
3ghsLDTAldose reductase1.1.1.210.652
2pdmZSTAldose reductase1.1.1.210.650
2hvoZSTAldose reductase1.1.1.210.649
2duzZSTAldose reductase1.1.1.210.648
2i17LDTAldose reductase1.1.1.210.620
3ghuLDTAldose reductase1.1.1.210.616
2duxZSTAldose reductase1.1.1.210.605
2iki388Aldose reductase1.1.1.210.603
3m64393Aldose reductase1.1.1.210.601
2pdlTOLAldose reductase1.1.1.210.594
2pdfZSTAldose reductase1.1.1.210.593
2pdh47DAldose reductase1.1.1.210.593
2pdg47DAldose reductase1.1.1.210.581
3g5eQ74Aldose reductase1.1.1.210.581
1us0LDTAldose reductase1.1.1.210.580
2i16LDTAldose reductase1.1.1.210.578
2ikj393Aldose reductase1.1.1.210.576
1z3n3NAAldose reductase1.1.1.210.574
1pwmFIDAldose reductase1.1.1.210.568
2pdj393Aldose reductase1.1.1.210.567
2pdu393Aldose reductase1.1.1.210.564
2pdn47DAldose reductase1.1.1.210.554
3ld5LDTAldose reductase1.1.1.210.552
1z8962PAldose reductase1.1.1.210.550
2pdbZSTAldose reductase1.1.1.210.550
4gca2X9Aldose reductase1.1.1.210.549
2dv0ZSTAldose reductase1.1.1.210.546
2hvnZSTAldose reductase1.1.1.210.543
3mb9ZSTAldose reductase1.1.1.210.542
1t41ID5Aldose reductase1.1.1.210.541
3lenZSTAldose reductase1.1.1.210.535
3lqlLDTAldose reductase1.1.1.210.535
2hv5ZSTAldose reductase1.1.1.210.534
2ikhLITAldose reductase1.1.1.210.533
2qxwLDTAldose reductase1.1.1.210.532
2pd5ZSTAldose reductase1.1.1.210.531
3m0iZSTAldose reductase1.1.1.210.527
2pzn393Aldose reductase1.1.1.210.523
1pwlBFIAldose reductase1.1.1.210.515
2fz9ZSTAldose reductase1.1.1.210.513
3mc5393Aldose reductase1.1.1.210.512
3t423T4Aldose reductase1.1.1.210.510
1ieiZESAldose reductase1.1.1.210.508
1t40ID5Aldose reductase1.1.1.210.507
1zuaTOLAldo-keto reductase family 1 member B101.1.10.505
3lboLDTAldose reductase1.1.1.210.502
2fzbTOLAldose reductase1.1.1.210.501
2pdc393Aldose reductase1.1.1.210.501
1el3I84Aldose reductase1.1.1.210.498
4dbuBT9Aldo-keto reductase family 1 member C3/0.497
2pdq47DAldose reductase1.1.1.210.496
2pdxZSTAldose reductase1.1.1.210.494
1ah3TOLAldose reductase1.1.1.210.485
3lz5LDTAldose reductase1.1.1.210.485
1frbZSTAldose reductase-related protein 2/0.483
3m4h388Aldose reductase1.1.1.210.479
3pqbVGPPutative oxidoreductase/0.479
2f3815MAldo-keto reductase family 1 member C3/0.477
3ug8IMNAldo-keto reductase family 1 member C3/0.476
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.472
4xwtU5PRibonuclease J/0.472
2fzdTOLAldose reductase1.1.1.210.468
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
4yu153NAldose reductase1.1.1.210.468
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
3p2vDOYAldose reductase1.1.1.210.466
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.463
4dbw511Aldo-keto reductase family 1 member C3/0.463
1ry0PG2Aldo-keto reductase family 1 member C3/0.462
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.459
2cekN8TAcetylcholinesterase3.1.1.70.458
2pdkSBIAldose reductase1.1.1.210.458
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.458
1q83TZ5Acetylcholinesterase3.1.1.70.457
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.457
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.457
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.456
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.455
1obnASVIsopenicillin N synthase1.21.3.10.453
3ugrIMNAldo-keto reductase family 1 member C3/0.451
1odcA8BAcetylcholinesterase3.1.1.70.450
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.450
3v94WYQPhosphodiesterase/0.449
1xzqFONtRNA modification GTPase MnmE3.6.50.448
3n0hTOPDihydrofolate reductase1.5.1.30.446
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.446
2aovC2MHistamine N-methyltransferase2.1.1.80.445
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.445
3r8hZOMAldo-keto reductase family 1 member C3/0.445
2cmfF11Acetylcholinesterase3.1.1.70.444
2jg7NADAntiquitin/0.444
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.443
2w6cBM4Acetylcholinesterase3.1.1.70.443
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.443
1s36CEIObelin/0.442
1u65CP0Acetylcholinesterase3.1.1.70.441
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.441
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.441
2v0mKLNCytochrome P450 3A4/0.440
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.440
5liu388Aldo-keto reductase family 1 member B101.1.10.440