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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pdg47DAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pdg47DAldose reductase1.1.1.211.000
2duxZSTAldose reductase1.1.1.210.668
2hvoZSTAldose reductase1.1.1.210.664
2pdh47DAldose reductase1.1.1.210.631
3ld5LDTAldose reductase1.1.1.210.628
2duzZSTAldose reductase1.1.1.210.627
2pdmZSTAldose reductase1.1.1.210.618
2i17LDTAldose reductase1.1.1.210.614
3ghtLDTAldose reductase1.1.1.210.603
4yu153NAldose reductase1.1.1.210.602
2pdiZSTAldose reductase1.1.1.210.601
3mb9ZSTAldose reductase1.1.1.210.600
2pdfZSTAldose reductase1.1.1.210.598
2pd5ZSTAldose reductase1.1.1.210.590
3ghsLDTAldose reductase1.1.1.210.589
2qxwLDTAldose reductase1.1.1.210.588
3g5eQ74Aldose reductase1.1.1.210.587
4gca2X9Aldose reductase1.1.1.210.580
1t41ID5Aldose reductase1.1.1.210.578
2pdn47DAldose reductase1.1.1.210.578
2pdbZSTAldose reductase1.1.1.210.575
2pdxZSTAldose reductase1.1.1.210.574
3ghrLDTAldose reductase1.1.1.210.574
1z8962PAldose reductase1.1.1.210.573
3m64393Aldose reductase1.1.1.210.573
3lboLDTAldose reductase1.1.1.210.571
3m4h388Aldose reductase1.1.1.210.569
2ikj393Aldose reductase1.1.1.210.568
3lenZSTAldose reductase1.1.1.210.565
2fz8ZSTAldose reductase1.1.1.210.564
2pdp393Aldose reductase1.1.1.210.564
2pdj393Aldose reductase1.1.1.210.562
1z3n3NAAldose reductase1.1.1.210.561
2hvnZSTAldose reductase1.1.1.210.558
1pwlBFIAldose reductase1.1.1.210.557
2pdu393Aldose reductase1.1.1.210.557
1t40ID5Aldose reductase1.1.1.210.554
3m0iZSTAldose reductase1.1.1.210.553
2pdc393Aldose reductase1.1.1.210.552
3ghuLDTAldose reductase1.1.1.210.551
2pzn393Aldose reductase1.1.1.210.548
3lqlLDTAldose reductase1.1.1.210.547
3lz5LDTAldose reductase1.1.1.210.546
3t423T4Aldose reductase1.1.1.210.545
2iki388Aldose reductase1.1.1.210.544
2fz9ZSTAldose reductase1.1.1.210.540
1us0LDTAldose reductase1.1.1.210.537
1frbZSTAldose reductase-related protein 2/0.535
2dv0ZSTAldose reductase1.1.1.210.535
2i16LDTAldose reductase1.1.1.210.531
3mc5393Aldose reductase1.1.1.210.519
2ikhLITAldose reductase1.1.1.210.515
1ieiZESAldose reductase1.1.1.210.510
1zuaTOLAldo-keto reductase family 1 member B101.1.10.509
2hv5ZSTAldose reductase1.1.1.210.503
2agtFIDAldose reductase1.1.1.210.493
2pdq47DAldose reductase1.1.1.210.488
4li61XOTankyrase-12.4.2.300.486
3s3gTLTAldose reductase1.1.1.210.483
2f2kTGGAldose reductase1.1.1.210.481
2pdlTOLAldose reductase1.1.1.210.475
4wevSUZAldo-keto reductase family 1 member B101.1.10.474
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.473
1ah3TOLAldose reductase1.1.1.210.469
2aovC2MHistamine N-methyltransferase2.1.1.80.469
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.467
5liu388Aldo-keto reductase family 1 member B101.1.10.466
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.465
2fzdTOLAldose reductase1.1.1.210.462
1esmCOAPantothenate kinase2.7.1.330.460
1q23FUAChloramphenicol acetyltransferase2.3.1.280.460
1el3I84Aldose reductase1.1.1.210.457
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.457
2xupTZ5Acetylcholinesterase3.1.1.70.455
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.453
3v94WYQPhosphodiesterase/0.453
4j7hTRHPCZA361.3/0.453
4hyf1AKTankyrase-22.4.2.300.450
2xuhTZ4Acetylcholinesterase3.1.1.70.448
4e0u0MVCyclic dipeptide N-prenyltransferase/0.448
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.448
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.446
4dbw511Aldo-keto reductase family 1 member C3/0.445
3b82NADExotoxin A2.4.2.360.444
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3zhuTD8Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.443
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.443
4xwtU5PRibonuclease J/0.443
3pqbVGPPutative oxidoreductase/0.441
4bj9UHBTankyrase-22.4.2.300.441
3f3y4OABile salt sulfotransferase2.8.2.140.440
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.440