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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pdfZSTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pdfZSTAldose reductase1.1.1.211.000
2pdu393Aldose reductase1.1.1.210.652
2pdh47DAldose reductase1.1.1.210.624
2pdj393Aldose reductase1.1.1.210.578
2pdlTOLAldose reductase1.1.1.210.568
2pdmZSTAldose reductase1.1.1.210.551
2fz8ZSTAldose reductase1.1.1.210.546
2hvoZSTAldose reductase1.1.1.210.545
2dv0ZSTAldose reductase1.1.1.210.538
2pdq47DAldose reductase1.1.1.210.537
1t40ID5Aldose reductase1.1.1.210.536
2hvnZSTAldose reductase1.1.1.210.535
2pdiZSTAldose reductase1.1.1.210.535
4gca2X9Aldose reductase1.1.1.210.529
2hv5ZSTAldose reductase1.1.1.210.526
2pdn47DAldose reductase1.1.1.210.526
2iki388Aldose reductase1.1.1.210.520
2ikj393Aldose reductase1.1.1.210.516
1z8962PAldose reductase1.1.1.210.515
3t423T4Aldose reductase1.1.1.210.514
1z3n3NAAldose reductase1.1.1.210.513
2pdxZSTAldose reductase1.1.1.210.513
2duzZSTAldose reductase1.1.1.210.512
2fzdTOLAldose reductase1.1.1.210.512
2pdg47DAldose reductase1.1.1.210.510
3mc5393Aldose reductase1.1.1.210.510
1t41ID5Aldose reductase1.1.1.210.509
1zuaTOLAldo-keto reductase family 1 member B101.1.10.508
3ghuLDTAldose reductase1.1.1.210.508
3m64393Aldose reductase1.1.1.210.508
2fz9ZSTAldose reductase1.1.1.210.507
2pzn393Aldose reductase1.1.1.210.504
3ghtLDTAldose reductase1.1.1.210.503
2i17LDTAldose reductase1.1.1.210.501
2fzbTOLAldose reductase1.1.1.210.498
3g5eQ74Aldose reductase1.1.1.210.498
2i16LDTAldose reductase1.1.1.210.496
3ld5LDTAldose reductase1.1.1.210.496
3m4h388Aldose reductase1.1.1.210.496
3ghsLDTAldose reductase1.1.1.210.495
1ah3TOLAldose reductase1.1.1.210.494
3ghrLDTAldose reductase1.1.1.210.494
3p2vDOYAldose reductase1.1.1.210.493
2duxZSTAldose reductase1.1.1.210.492
3lboLDTAldose reductase1.1.1.210.492
1ieiZESAldose reductase1.1.1.210.491
3m0iZSTAldose reductase1.1.1.210.491
1us0LDTAldose reductase1.1.1.210.490
2pdp393Aldose reductase1.1.1.210.489
2qxwLDTAldose reductase1.1.1.210.488
3lz5LDTAldose reductase1.1.1.210.485
2pd5ZSTAldose reductase1.1.1.210.484
2pdc393Aldose reductase1.1.1.210.480
1pwlBFIAldose reductase1.1.1.210.478
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.478
3lenZSTAldose reductase1.1.1.210.475
4yu153NAldose reductase1.1.1.210.475
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.474
2f2kTGGAldose reductase1.1.1.210.473
2pdbZSTAldose reductase1.1.1.210.473
3lqlLDTAldose reductase1.1.1.210.472
2agtFIDAldose reductase1.1.1.210.471
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.471
1ekoI84Aldose reductase1.1.1.210.470
2inzOHPAldose reductase1.1.1.210.468
3v94WYQPhosphodiesterase/0.463
5liu388Aldo-keto reductase family 1 member B101.1.10.459
1ef3FIDAldose reductase1.1.1.210.458
3mb9ZSTAldose reductase1.1.1.210.454
3hggCHDCmeR/0.453
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.452
1frbZSTAldose reductase-related protein 2/0.451
4dbw511Aldo-keto reductase family 1 member C3/0.451
4fam0SZAldo-keto reductase family 1 member C3/0.451
1ry0PG2Aldo-keto reductase family 1 member C3/0.450
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.450
2ikhLITAldose reductase1.1.1.210.448
4arbC57Acetylcholinesterase3.1.1.70.447
1zgcA2EAcetylcholinesterase3.1.1.70.445
2f3815MAldo-keto reductase family 1 member C3/0.444
2pdwFIDAldose reductase1.1.1.210.443
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442