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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2iq0NAPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2iq0NAPAldose reductase1.1.1.211.000
1az2NAPAldose reductase1.1.1.210.781
1x96NAPAldose reductase1.1.1.210.729
2acsNAPAldose reductase1.1.1.210.700
2acqNAPAldose reductase1.1.1.210.690
1x98NAPAldose reductase1.1.1.210.665
2pf8NDPAldose reductase1.1.1.210.656
2pevNDPAldose reductase1.1.1.210.635
2pfhNDPAldose reductase1.1.1.210.633
1z8aNAPAldose reductase1.1.1.210.629
2acuNAPAldose reductase1.1.1.210.618
3v36NAPAldose reductase1.1.1.210.618
3q65NAPAldose reductase1.1.1.210.617
1ah4NAPAldose reductase1.1.1.210.614
2j8tNAPAldose reductase1.1.1.210.614
3q67NAPAldose reductase1.1.1.210.588
3qkzNAPAldose reductase-related protein 11.1.1.210.565
1adsNAPAldose reductase1.1.1.210.555
3h7rNAPAldo-keto reductase family 4 member C8/0.554
2hejNDPAldo-keto reductase family 1 member C211.1.10.546
3o3rNAPAldose reductase-related protein 11.1.1.210.540
4g5dNDPProstaglandin F synthase1.1.1.1880.538
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.534
1c9wNAPAldose reductase-related protein 2/0.529
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.528
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.522
4pmjNAPPutative oxidoreductase/0.509
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.502
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.500
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.497
1vp5NAPOxidoreductase, aldo/keto reductase family/0.493
4xo7NAPAldo-keto reductase family 1 member C2/0.493
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.491
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.485
1s1rNAPAldo-keto reductase family 1 member C3/0.482
1lqaNDPProtein tas/0.481
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.479
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.478
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.476
1ef3NAPAldose reductase1.1.1.210.475
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.472
1zgdNAPChalcone reductase/0.471
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.465
2p5nNDPAldo-keto reductase family 1 member C211.1.10.463
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.462
3wczNAPAldo-keto reductase AKR2E4/0.461
4jtqNAPAldo-keto reductase family 1 member C2/0.459
1pz1NAPGeneral stress protein 69/0.457
4xzmNAPAldo-keto reductase family 1 member B101.1.10.456
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.453
2hdjNDPAldo-keto reductase family 1 member C2/0.452
4l1xNAPAldo-keto reductase family 1 member C2/0.451
4dz5NAPAldo-keto reductase family 1 member C3/0.449
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.448
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.446
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.445
4xznNAPAldo-keto reductase family 1 member B101.1.10.444
1z9aNADNAD(P)H-dependent D-xylose reductase1.1.1.3070.442
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.441