sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2imf | TOM | 2-hydroxychromene-2-carboxylate isomerase | 5.99.1.4 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2imf | TOM | 2-hydroxychromene-2-carboxylate isomerase | 5.99.1.4 | 1.000 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.470 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.467 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 1fml | RTL | Retinol dehydratase | / | 0.455 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.455 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.455 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.448 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.448 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.447 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.446 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.446 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.446 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1m8h | 6NI | Nitric oxide synthase, inducible | 1.14.13.39 | 0.445 | |
| 4k9v | 6AW | Cytochrome P450 3A4 | / | 0.445 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.444 | |
| 4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.444 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.443 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.442 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.442 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.441 | |
| 3rpn | GTX | Glutathione S-transferase kappa 1 | 2.5.1.18 | 0.441 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.440 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.440 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 |