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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hp2KE4Glutamate-1-semialdehyde 2,1-aminomutase5.4.3.8

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hp2KE4Glutamate-1-semialdehyde 2,1-aminomutase5.4.3.81.000
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.486
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.463
3h3r14HCollagen type IV alpha-3-binding protein/0.463
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.461
4eb7PLPCysteine desulfurase IscS 2/0.461
3h3qH13Collagen type IV alpha-3-binding protein/0.457
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.457
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.455
1wkgPOI[LysW]-aminoadipate semialdehyde transaminase/0.454
1ahgTYR_PLPAspartate aminotransferase2.6.1.10.451
3fhxPLPPyridoxal kinase2.7.1.350.451
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.449
4lez1SYCyclic GMP-AMP synthase/0.449
1toiHCIAspartate aminotransferase2.6.1.10.447
3hl0NADMaleylacetate reductase/0.444
3v0o4GWHisto-blood group ABO system transferase/0.443
4e2yJHZMethyltransferase/0.443
1yryMSGPurine nucleoside phosphorylase2.4.2.10.442
2whqHI6Acetylcholinesterase3.1.1.70.441
3mauEXTPutative sphingosine-1-phosphate lyase/0.440
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.440