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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hdjNDPAldo-keto reductase family 1 member C2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hdjNDPAldo-keto reductase family 1 member C2/1.000
4xo7NAPAldo-keto reductase family 1 member C2/0.646
4jtqNAPAldo-keto reductase family 1 member C2/0.626
4jq3NAPAldo-keto reductase family 1 member C2/0.603
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.602
4l1xNAPAldo-keto reductase family 1 member C2/0.601
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.583
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.561
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.555
4dz5NAPAldo-keto reductase family 1 member C3/0.547
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.534
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.526
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.524
1s1rNAPAldo-keto reductase family 1 member C3/0.523
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.520
2hejNDPAldo-keto reductase family 1 member C211.1.10.509
4pmjNAPPutative oxidoreductase/0.501
1c9wNAPAldose reductase-related protein 2/0.491
1zgdNAPChalcone reductase/0.483
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.478
3h7rNAPAldo-keto reductase family 4 member C8/0.476
2acqNAPAldose reductase1.1.1.210.475
2p5nNDPAldo-keto reductase family 1 member C211.1.10.472
1s1pNAPAldo-keto reductase family 1 member C3/0.471
3o3rNAPAldose reductase-related protein 11.1.1.210.471
5c7hNDPPutative oxidoreductase/0.469
1ah4NAPAldose reductase1.1.1.210.468
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.466
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.463
1x96NAPAldose reductase1.1.1.210.463
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.462
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.460
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.459
1x98NAPAldose reductase1.1.1.210.456
1z8aNAPAldose reductase1.1.1.210.454
2iq0NAPAldose reductase1.1.1.210.453
2j8tNAPAldose reductase1.1.1.210.453
3wczNAPAldo-keto reductase AKR2E4/0.453
1adsNAPAldose reductase1.1.1.210.452
1az2NAPAldose reductase1.1.1.210.452
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.452
2clpNDPAflatoxin B1 aldehyde reductase member 3/0.451
3q67NAPAldose reductase1.1.1.210.450
2pf8NDPAldose reductase1.1.1.210.447
3q65NAPAldose reductase1.1.1.210.445
3qkzNAPAldose reductase-related protein 11.1.1.210.444
2he5NDPAldo-keto reductase family 1 member C211.1.10.441
3v36NAPAldose reductase1.1.1.210.441
1pz1NAPGeneral stress protein 69/0.440