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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2gh6CF3Histone deacetylase-like amidohydrolase3.5.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2gh6CF3Histone deacetylase-like amidohydrolase3.5.11.000
2vcgS17Histone deacetylase-like amidohydrolase3.5.10.559
1zz1SHHHistone deacetylase-like amidohydrolase3.5.10.513
4bz7B3NHistone deacetylase/0.480
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.474
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.468
1e6eFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.467
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.459
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.455
3pwhZMAAdenosine receptor A2a/0.454
4isf1FXGlucokinase2.7.1.20.452
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.451
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
3h3sH15Collagen type IV alpha-3-binding protein/0.443
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.442
5bt42LOBromodomain-containing protein 4/0.442
1x8lOXRRetinol dehydratase/0.440
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.440