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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2gh5FADGlutathione reductase, mitochondrial1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2gh5FADGlutathione reductase, mitochondrial1.8.1.71.000
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.612
1graFADGlutathione reductase, mitochondrial1.8.1.70.600
1greFADGlutathione reductase, mitochondrial1.8.1.70.595
1grhFADGlutathione reductase, mitochondrial1.8.1.70.590
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.586
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.584
1grgFADGlutathione reductase, mitochondrial1.8.1.70.581
3grsFADGlutathione reductase, mitochondrial1.8.1.70.580
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.578
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.576
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.574
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.573
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.571
2r9zFADGlutathione amide reductase/0.551
2v6oFADThioredoxin glutathione reductase/0.531
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.516
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.512
1gerFADGlutathione reductase1.8.1.70.511
1grbFADGlutathione reductase, mitochondrial1.8.1.70.510
2rabFADGlutathione amide reductase/0.508
3djgFADGlutathione reductase, mitochondrial1.8.1.70.504
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.496
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.484
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.483
1geuFADGlutathione reductase1.8.1.70.480
1febFADTrypanothione reductase1.8.1.120.476
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.473
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.471
3ic9FADPutative dihydrolipoamide dehydrogenase/0.459