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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2g8dUMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2g8dUMPThymidylate synthase/1.000
2g8aUMPThymidylate synthase/0.762
2g89UMPThymidylate synthase/0.723
1jmhUMPThymidylate synthase/0.660
1njbUMPThymidylate synthase/0.654
2g86UMPThymidylate synthase/0.650
1tsvUMPThymidylate synthase/0.643
1njcDCMThymidylate synthase/0.633
1njeDCMThymidylate synthase/0.621
1bp6UMPThymidylate synthase/0.619
1bp0UMPThymidylate synthase/0.592
1tdcUMPThymidylate synthase/0.589
1tsyUMPThymidylate synthase/0.587
1njdUMPThymidylate synthase/0.586
1njaDCMThymidylate synthase/0.583
1jmfUMPThymidylate synthase/0.577
1jmiUMPThymidylate synthase/0.570
1vzaUMPThymidylate synthase/0.569
1lcbTMPThymidylate synthase/0.561
4einNOHThymidylate synthase2.1.1.450.561
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.556
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.555
1bpjUMPThymidylate synthase/0.554
2tdmUMPThymidylate synthase/0.554
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.545
1lcbDHFThymidylate synthase/0.544
4e5oUMPThymidylate synthase2.1.1.450.542
1bidUMPThymidylate synthase/0.540
1jmgUMPThymidylate synthase/0.538
1tsxUMPThymidylate synthase/0.533
3qj7UMPThymidylate synthase ThyA/0.528
4dq1UMPThymidylate synthase/0.527
2vf0F89Thymidylate synthase/0.521
4eb4UMPThymidylate synthase2.1.1.450.501
1j3jUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.497
1bduDURThymidylate synthase/0.487
1vzbUMPThymidylate synthase/0.484
4h0uUMPThymidylate synthase/0.484
4iskUMPThymidylate synthase/0.484
2vetUMPThymidylate synthase/0.481
3hb8UMPThymidylate synthase2.1.1.450.478
1aobDDUThymidylate synthase/0.469
4irrUMPThymidylate synthase/0.467
1tlcF89Thymidylate synthase/0.457
2ftoCB3Thymidylate synthase/0.455
4xsdUMPThymidylate synthase2.1.1.450.455
5by6UMPThymidylate synthase/0.450
1f28UMPThymidylate synthase2.1.1.450.449
2ftoTMPThymidylate synthase/0.448
1dduCB3Thymidylate synthase/0.444
3bgxTMPThymidylate synthase/0.441