scPDB - Distribution of Binding site Similarity values of 2fzi entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2fzi	DH3	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	1.000
3qly	55V	Uncharacterized protein	/	0.634
3cse	N22	Uncharacterized protein	/	0.621
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.619
3eek	53S	Uncharacterized protein	/	0.616
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.602
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.598
4h98	14Q	Uncharacterized protein	/	0.594
3eej	53R	Uncharacterized protein	/	0.592
3qlz	QLZ	Uncharacterized protein	/	0.592
3eel	53T	Uncharacterized protein	/	0.590
3qlx	QLR	Uncharacterized protein	/	0.589
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.589
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.582
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.578
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.578
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.578
3eem	53V	Uncharacterized protein	/	0.577
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.569
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.567
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.566
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.564
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.563
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.561
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.553
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.552
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.550
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.546
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.545
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.545
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.542
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.541
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.539
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.536
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.534
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.531
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.528
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.526
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.525
2w3v	TOP	Dihydrofolate reductase	/	0.524
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.519
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.517
2zza	FOL	Dihydrofolate reductase	/	0.517
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.515
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.511
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.508
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.506
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.506
3jwm	5WB	Dihydrofolate reductase	/	0.504
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.502
3ia4	MTX	Dihydrofolate reductase	/	0.502
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.501
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.501
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.499
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.499
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.498
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.496
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.494
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.493
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.492
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.482
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.480
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.479
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.479
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.477
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.477
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.476
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.476
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.475
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.475
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.474
4ele	31I	Dihydrofolate reductase	/	0.473
3sa2	7DR	Dihydrofolate reductase	/	0.472
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.472
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.470
3jw5	TOP	Dihydrofolate reductase	/	0.469
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.469
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.468
2w3w	VG9	Dihydrofolate reductase	/	0.468
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.467
4ia7	BIV	Vitamin D3 receptor A	/	0.466
3fl8	RAR	Dihydrofolate reductase	/	0.465
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.464
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.464
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.463
4j6c	STR	Cytochrome P450 monooxygenase	/	0.462
3fy9	XCF	Dihydrofolate reductase	1.5.1.3	0.461
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.460
3jwc	EKB	Dihydrofolate reductase	/	0.459
3tqb	FOL	Dihydrofolate reductase	/	0.459
4hw3	19G	Induced myeloid leukemia cell differentiation protein Mcl-1	/	0.458
4ia2	BIV	Vitamin D3 receptor A	/	0.458
3dau	MTX	Dihydrofolate reductase	1.5.1.3	0.457
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.457
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.457
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.457
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.454
3sh2	5DR	Dihydrofolate reductase	1.5.1.3	0.454
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.453
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.453
4p66	MTX	Dihydrofolate reductase	/	0.453
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.452
3fra	I2H	Dihydrofolate reductase	1.5.1.3	0.452
3irx	UDR	Gag-Pol polyprotein	2.7.7.49	0.451
4kjj	FOL	Dihydrofolate reductase	1.5.1.3	0.451
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.450
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.450
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.450
4bch	T7Z	Cyclin-dependent kinase 9	2.7.11.22	0.450
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.450
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.449
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.449
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.449
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.448
2qbl	CAM	Camphor 5-monooxygenase	1.14.15.1	0.448
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.448
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.448
4jbt	ASD	Cytochrome P450 monooxygenase	/	0.448
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.448
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.448
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.447
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.447
3tq9	MTX	Dihydrofolate reductase	/	0.447
4ia1	BIV	Vitamin D3 receptor A	/	0.447
4ia3	BIV	Vitamin D3 receptor A	/	0.447
4iui	1GQ	Estrogen receptor	/	0.447
4j03	FVS	Bifunctional epoxide hydrolase 2	3.1.3.76	0.447
4fgh	0U6	Dihydrofolate reductase	1.5.1.3	0.446
3m08	RAR	Dihydrofolate reductase	1.5.1.3	0.445
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.445
4ib4	ERM	5-hydroxytryptamine receptor 2B	/	0.445
2pnu	ENM	Androgen receptor	/	0.443
2qo4	CHD	Fatty acid-binding protein 10-A, liver basic	/	0.443
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.443
3jw3	TOP	Dihydrofolate reductase	/	0.443
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.443
3sa1	6DR	Dihydrofolate reductase	/	0.443
3u8h	BHP	Phospholipase A2, membrane associated	/	0.443
3v94	WYQ	Phosphodiesterase	/	0.443
4elg	52J	Dihydrofolate reductase	/	0.443
1fp1	HCC	Isoliquiritigenin 2'-O-methyltransferase	/	0.442
1kzj	CB3	Thymidylate synthase	/	0.442
2jb4	A14	Isopenicillin N synthase	1.21.3.1	0.442
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.442
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.442
3dl9	V2H	Vitamin D 25-hydroxylase	/	0.441
1fm4	DXC	Major pollen allergen Bet v 1-L	/	0.440
1qkn	RAL	Estrogen receptor beta	/	0.440
4elb	34R	Dihydrofolate reductase	/	0.440