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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2fz8ZSTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2fz8ZSTAldose reductase1.1.1.211.000
2pdmZSTAldose reductase1.1.1.210.752
2iki388Aldose reductase1.1.1.210.668
2hv5ZSTAldose reductase1.1.1.210.665
2pdiZSTAldose reductase1.1.1.210.665
2i16LDTAldose reductase1.1.1.210.662
2dv0ZSTAldose reductase1.1.1.210.648
3ghrLDTAldose reductase1.1.1.210.642
2fz9ZSTAldose reductase1.1.1.210.631
1z8962PAldose reductase1.1.1.210.618
3ghsLDTAldose reductase1.1.1.210.615
2hvoZSTAldose reductase1.1.1.210.614
2ikj393Aldose reductase1.1.1.210.602
1z3n3NAAldose reductase1.1.1.210.600
3ghtLDTAldose reductase1.1.1.210.595
3mb9ZSTAldose reductase1.1.1.210.592
2pdlTOLAldose reductase1.1.1.210.589
1t40ID5Aldose reductase1.1.1.210.584
2ikhLITAldose reductase1.1.1.210.583
2duzZSTAldose reductase1.1.1.210.581
2qxwLDTAldose reductase1.1.1.210.577
2hvnZSTAldose reductase1.1.1.210.573
2pdh47DAldose reductase1.1.1.210.572
2pdxZSTAldose reductase1.1.1.210.567
3g5eQ74Aldose reductase1.1.1.210.567
4gca2X9Aldose reductase1.1.1.210.567
3ghuLDTAldose reductase1.1.1.210.562
3m64393Aldose reductase1.1.1.210.562
3lqlLDTAldose reductase1.1.1.210.557
2pdfZSTAldose reductase1.1.1.210.556
2pdu393Aldose reductase1.1.1.210.555
1t41ID5Aldose reductase1.1.1.210.553
2pzn393Aldose reductase1.1.1.210.548
2pdwFIDAldose reductase1.1.1.210.547
2i17LDTAldose reductase1.1.1.210.546
2pdbZSTAldose reductase1.1.1.210.546
3ld5LDTAldose reductase1.1.1.210.543
2pd5ZSTAldose reductase1.1.1.210.542
2pdp393Aldose reductase1.1.1.210.541
3lboLDTAldose reductase1.1.1.210.537
1ieiZESAldose reductase1.1.1.210.531
3lenZSTAldose reductase1.1.1.210.531
3m4h388Aldose reductase1.1.1.210.530
2pdyFIDAldose reductase1.1.1.210.522
2pdg47DAldose reductase1.1.1.210.521
3t423T4Aldose reductase1.1.1.210.514
2pdc393Aldose reductase1.1.1.210.509
3m0iZSTAldose reductase1.1.1.210.508
2duxZSTAldose reductase1.1.1.210.507
2pdn47DAldose reductase1.1.1.210.505
2iqdLPAAldose reductase1.1.1.210.501
3mc5393Aldose reductase1.1.1.210.501
1us0LDTAldose reductase1.1.1.210.497
2pdj393Aldose reductase1.1.1.210.497
1pwlBFIAldose reductase1.1.1.210.496
2inzOHPAldose reductase1.1.1.210.495
1zuaTOLAldo-keto reductase family 1 member B101.1.10.494
2fzdTOLAldose reductase1.1.1.210.481
1frbZSTAldose reductase-related protein 2/0.480
2f2kTGGAldose reductase1.1.1.210.471
3lz5LDTAldose reductase1.1.1.210.468
4yu153NAldose reductase1.1.1.210.461
2agtFIDAldose reductase1.1.1.210.450
2pdq47DAldose reductase1.1.1.210.449
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.447
3s3gTLTAldose reductase1.1.1.210.443