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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ejzSAHDiphthine synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ejzSAHDiphthine synthase/1.000
2ed3SAHDiphthine synthase/0.570
2owfSAHDiphthine synthase/0.569
2emuSAHDiphthine synthase/0.545
2e16SAHDiphthine synthase/0.539
1vceSAHDiphthine synthase/0.537
2huvSAHDiphthine synthase/0.533
2ehlSAHDiphthine synthase/0.529
2emrSAHDiphthine synthase/0.529
2eleSAHDiphthine synthase/0.527
2pb6SAHDiphthine synthase/0.526
2e07SAHDiphthine synthase/0.523
2e08SAHDiphthine synthase/0.523
2p6dSAHDiphthine synthase/0.522
2dshSAHDiphthine synthase/0.521
2owgSAHDiphthine synthase/0.520
2dv4SAHDiphthine synthase/0.519
2pb4SAHDiphthine synthase/0.518
2e17SAHDiphthine synthase/0.517
2p6kSAHDiphthine synthase/0.517
2dekSAHDiphthine synthase/0.515
2p6lSAHDiphthine synthase/0.515
2e7rSAHDiphthine synthase/0.514
2eeqSAHDiphthine synthase/0.514
2ed5SAHDiphthine synthase/0.513
2dsgSAHDiphthine synthase/0.512
2ejkSAHDiphthine synthase/0.512
2pcgSAHDiphthine synthase/0.512
2e15SAHDiphthine synthase/0.510
2owuSAHDiphthine synthase/0.510
2dsiSAHDiphthine synthase/0.509
2pckSAHDiphthine synthase/0.509
2pcaSAHDiphthine synthase/0.508
2z6rSAHDiphthine synthase/0.508
2e8rSAHDiphthine synthase/0.507
2eh5SAHDiphthine synthase/0.507
2p9dSAHDiphthine synthase/0.507
2p5cSAHDiphthine synthase/0.505
2p5fSAHDiphthine synthase/0.505
2e4nSAHDiphthine synthase/0.504
2huxSAHDiphthine synthase/0.504
2hr8SAHDiphthine synthase/0.503
2owkSAHDiphthine synthase/0.503
2e8hSAHDiphthine synthase/0.502
2eniSAHDiphthine synthase/0.502
2ek7SAHDiphthine synthase/0.501
2eldSAHDiphthine synthase/0.501
2el0SAHDiphthine synthase/0.500
2p6iSAHDiphthine synthase/0.500
2pchSAHDiphthine synthase/0.500
2pcmSAHDiphthine synthase/0.500
2e8qSAHDiphthine synthase/0.499
2ek4SAHDiphthine synthase/0.498
2owvSAHDiphthine synthase/0.498
2egbSAHDiphthine synthase/0.496
2eh4SAHDiphthine synthase/0.496
2dv7SAHDiphthine synthase/0.495
2e8sSAHDiphthine synthase/0.494
2dxvSAHDiphthine synthase/0.493
2dv3SAHDiphthine synthase/0.492
2ek2SAHDiphthine synthase/0.492
2el3SAHDiphthine synthase/0.490
2huqSAHDiphthine synthase/0.490
2dv5SAHDiphthine synthase/0.489
2ekaSAHDiphthine synthase/0.489
1wngSAHDiphthine synthase/0.488
2dxwSAHDiphthine synthase/0.488
2eglSAHDiphthine synthase/0.488
2eh2SAHDiphthine synthase/0.488
2hutSAHDiphthine synthase/0.488
2pciSAHDiphthine synthase/0.483
2ejjSAHDiphthine synthase/0.482
2pb5SAHDiphthine synthase/0.482
2ek3SAHDiphthine synthase/0.479
2p2xSAHDiphthine synthase/0.479
2dxxSAHDiphthine synthase/0.477
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.472
2en5SAHDiphthine synthase/0.472
4egbNADdTDP-glucose 4,6-dehydratase/0.470
2egsSAHDiphthine synthase/0.468
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.467
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.467
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.465
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.462
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.461
4frkDWDBeta-secretase 13.4.23.460.460
3gw9VNILanosterol 14-alpha-demethylase/0.458
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.454
3c1y2BADNA integrity scanning protein DisA/0.453
3pqbVGPPutative oxidoreductase/0.453
2g8yNADHydroxycarboxylate dehydrogenase B/0.452
3wv9FEGHmd co-occurring protein HcgE/0.452
1hb3SCVIsopenicillin N synthase1.21.3.10.451
4g3jVNTLanosterol 14-alpha-demethylase/0.451
4bfwZVWPantothenate kinase2.7.1.330.450
2ifaFMNUncharacterized protein/0.449
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.449
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
2x7hPFNProstaglandin reductase 310.447
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
1c7oPPGHemolysin/0.446
1fm4DXCMajor pollen allergen Bet v 1-L/0.446
2vcmM11Isopenicillin N synthase1.21.3.10.446
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
1pd9CO4Dihydrofolate reductase1.5.1.30.445
4g7gVFVLanosterol 14-alpha-demethylase/0.445
4a81DXCMajor pollen allergen Bet v 1-A/0.444
1g1aNADdTDP-glucose 4,6-dehydratase/0.443
1pqc444Oxysterols receptor LXR-beta/0.443
2iviACWIsopenicillin N synthase1.21.3.10.443
2rlcCHDCholoylglycine hydrolase3.5.1.240.443
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
1amoFMNNADPH--cytochrome P450 reductase/0.442
3lqfNADGalactitol dehydrogenase/0.441
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.440
4b7754MBeta-secretase 13.4.23.460.440
4b78KGGBeta-secretase 13.4.23.460.440