sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2e7f | C2F | 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase | 2.1.1.258 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2e7f | C2F | 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase | 2.1.1.258 | 1.000 | |
| 2ogy | C2F | 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase | 2.1.1.258 | 0.639 | |
| 3k13 | THH | 5-methyltetrahydrofolate-homocysteine methyltransferase | / | 0.555 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.468 | |
| 3pw8 | ACO | 1,2-phenylacetyl-CoA epoxidase, subunit A | 1.14.13.149 | 0.465 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 3dzv | ADP | Hydroxyethylthiazole kinase | / | 0.461 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.460 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.456 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.456 | |
| 1la2 | NAD | Inositol-3-phosphate synthase | 5.5.1.4 | 0.455 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.455 | |
| 2xbm | SAH | Genome polyprotein | / | 0.454 | |
| 2px5 | SAH | Genome polyprotein | 2.7.7.48 | 0.453 | |
| 4bvb | AR6 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.453 | |
| 2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.452 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.450 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.449 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.449 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.448 | |
| 3eld | SFG | Methyltransferase | / | 0.448 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.448 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.446 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1t02 | LVA | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.445 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.445 | |
| 4dja | FAD | (6-4) photolyase | / | 0.445 | |
| 4dna | FAD | Probable glutathione reductase | / | 0.444 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.442 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.442 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.441 |