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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2dwpACP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.105

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2dwpACP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1051.000
4ma4ADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.669
2i1vADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.602
3qpvADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.600
2axnADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3/0.582
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.547
1bifAGS6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.531
1k6mAGS6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 12.7.1.1050.529
1nzdUPGDNA beta-glucosyltransferase/0.478
1nzfUPGDNA beta-glucosyltransferase/0.474
3l8sBFFMitogen-activated protein kinase 14/0.461
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.450
3zk5Z18Cytochrome P450 monooxygenase PikC/0.450
4ia3BIVVitamin D3 receptor A/0.450
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.450
1kzjCB3Thymidylate synthase/0.449
3ibdCPZCytochrome P450 2B61.14.130.449
1k6cMK1Gag-Pol polyprotein3.4.23.160.446
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.446
4nb6444Nuclear receptor ROR-gamma/0.446
2ph5NADHomospermidine synthase/0.445
3iaeD7KBenzaldehyde lyase/0.445
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2hcdBIVVitamin D3 receptor A/0.441
4h3ySAHtRNA (guanine-N(1)-)-methyltransferase/0.441
3p99LNPLanosterol 14-alpha-demethylase/0.440
3vrwYS5Vitamin D3 receptor/0.440
4eh3NARMitogen-activated protein kinase 14/0.440
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.440