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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/1.000
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.546
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.544
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.521
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.512
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.512
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.509
3lqfNADGalactitol dehydrogenase/0.508
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.507
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.507
4nbwNADShort-chain dehydrogenase/reductase SDR/0.505
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.502
3gegNADShort-chain dehydrogenase/reductase SDR/0.500
4j7uNAPSepiapterin reductase1.1.1.1530.500
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.496
1ipeNDPTropinone reductase 21.1.1.2360.496
5jlaNADPutative short-chain dehydrogenase/reductase/0.494
1g6kNADGlucose 1-dehydrogenase1.1.1.470.493
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.490
4j7xNAPSepiapterin reductase1.1.1.1530.490
4hwkNAPSepiapterin reductase1.1.1.1530.489
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.487
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.486
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.481
4idgNADPutative UDP-glucose 4-epimerase/0.480
4yagNAIC alpha-dehydrogenase/0.477
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.476
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.476
4yaiNAIC alpha-dehydrogenase/0.476
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.476
1snyNAPLD36273p/0.475
3f1kNAPUncharacterized oxidoreductase YciK10.475
3sx2NADUncharacterized protein/0.475
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.475
4fn4NADShort chain dehydrogenase/0.475
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.474
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.474
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.474
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.473
3s55NADPutative short-chain dehydrogenase/reductase/0.473
1zemNADXylitol dehydrogenase/0.472
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.472
5idwNAPShort-chain dehydrogenase/reductase SDR/0.472
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.471
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.470
1ae1NAPTropinone reductase 1/0.469
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.469
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.469
3wdsNADNADH-dependent quinuclidinone reductase/0.469
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.468
5lc1NADL-threonine 3-dehydrogenase/0.468
1n5dNDPCarbonyl reductase [NADPH] 1/0.467
2wdzNADGalactitol dehydrogenase/0.467
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.467
1oaaNAPSepiapterin reductase1.1.1.1530.465
2dteNAIGlucose 1-dehydrogenase related protein/0.464
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.464
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
2wsbNADGalactitol dehydrogenase/0.462
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.461
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.461
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.461
3w8eNAD3-hydroxybutyrate dehydrogenase/0.460
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.460
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.459
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.459
4bmvNAPShort-chain dehydrogenase/0.459
4esoNAPPutative oxidoreductase/0.459
5jydNADShort chain dehydrogenase/0.459
1wntNAPL-xylulose reductase1.1.1.100.458
4gh5NADShort-chain dehydrogenase/reductase SDR/0.458
1iy8NADLevodione reductase/0.457
3ak4NADNADH-dependent quinuclidinone reductase/0.457
4qecNAPElxO/0.457
1gcoNADGlucose 1-dehydrogenase1.1.1.470.456
1geeNADGlucose 1-dehydrogenase1.1.1.470.456
3tscNADUncharacterized protein/0.456
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.453
1x7gNAPPutative ketoacyl reductase1.3.10.453
3vdqNAD3-hydroxybutyrate dehydrogenase/0.453
2bd0NAPSepiapterin reductase/0.452
1xg5NAPDehydrogenase/reductase SDR family member 11/0.451
3gy0NAPNAD(P)-dependent oxidoreductase/0.451
3toxNAPPutative oxidoreductase/0.451
1rwbNADGlucose 1-dehydrogenase1.1.1.470.450
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.449
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.449
2yy7NADL-threonine dehydrogenase/0.448
3d3wNAPL-xylulose reductase1.1.1.100.448
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.448
5ig2NADShort-chain dehydrogenase/reductase SDR/0.447
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.446
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.445
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.445
4b79NADProbable short-chain dehydrogenase/0.445
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.445
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.443
2yutNAPPutative short-chain oxidoreductase/0.443
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.442
3p19NDPPutative blue fluorescent protein/0.442
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.442
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441