sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial | / | 1.000 | |
| 4g1c | CNA | NAD-dependent protein deacylase sirtuin-5, mitochondrial | / | 0.536 | |
| 1m2h | APR | NAD-dependent protein deacylase 1 | / | 0.509 | |
| 1m2g | APR | NAD-dependent protein deacylase 1 | / | 0.493 | |
| 1m2k | APR | NAD-dependent protein deacylase 1 | / | 0.484 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.481 | |
| 4iao | APR | NAD-dependent histone deacetylase SIR2 | 3.5.1 | 0.476 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.475 | |
| 1m2j | APR | NAD-dependent protein deacylase 1 | / | 0.469 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.458 | |
| 4bvb | AR6 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.458 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.456 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.456 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.456 | |
| 1s7g | APR | NAD-dependent protein deacylase 2 | / | 0.455 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.455 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.452 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.451 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.451 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.449 | |
| 1yc2 | APR | NAD-dependent protein deacylase 2 | / | 0.448 | |
| 5e7o | MGD | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.448 | |
| 5dbg | NAD | Iridoid synthase | 1.3.1.99 | 0.447 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.446 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.445 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.444 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.444 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.443 | |
| 5d7q | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.442 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.441 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.441 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 |