sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2b0q | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2b0q | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 1.000 | |
| 3tm0 | ANP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.633 | |
| 2bkk | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.584 | |
| 1j7l | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.583 | |
| 3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.549 | |
| 1l8t | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.498 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.479 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.475 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.459 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.456 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.454 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.454 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.453 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.453 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.451 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.449 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.448 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.448 | |
| 4x81 | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.448 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.447 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4req | 5AD | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.446 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.445 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.445 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.442 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.440 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.440 |