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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.741
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.728
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.671
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.640
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.634
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.629
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.628
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.627
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.625
2ie0ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.611
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.597
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.591
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.579
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.577
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.573
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.566
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.560
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.551
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.545
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.537
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.533
1enzNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.532
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.513
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.513
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.497
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.489
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.488
1bk0ACVIsopenicillin N synthase1.21.3.10.482
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.482
3zoiM2WIsopenicillin N synthase1.21.3.10.471
2b36NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.470
2vn0TDZCytochrome P450 2C8/0.470
2jb4A14Isopenicillin N synthase1.21.3.10.469
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.469
2vbdV10Isopenicillin N synthase1.21.3.10.469
2iviACWIsopenicillin N synthase1.21.3.10.468
1g6kNADGlucose 1-dehydrogenase1.1.1.470.467
2b35NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
4q72FADBifunctional protein PutA/0.465
1jioDEB6-deoxyerythronolide B hydroxylase/0.463
3zkyWT4Isopenicillin N synthase1.21.3.10.463
2he5NDPAldo-keto reductase family 1 member C211.1.10.461
2zbaZBATrichothecene 3-O-acetyltransferase/0.461
3lqfNADGalactitol dehydrogenase/0.461
1hb3SCVIsopenicillin N synthase1.21.3.10.460
1qiqACCIsopenicillin N synthase1.21.3.10.460
1hb1OCVIsopenicillin N synthase1.21.3.10.457
4ipw1G7Mycocyclosin synthase1.14.21.90.456
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.456
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.453
2bu9HFVIsopenicillin N synthase1.21.3.10.450
2ph5NADHomospermidine synthase/0.449
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.449
3d84NDPDihydrofolate reductase1.5.1.30.449
1e3eNAIAlcohol dehydrogenase 41.1.1.10.448
2nnhREACytochrome P450 2C8/0.448
4g3jVNTLanosterol 14-alpha-demethylase/0.447
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.446
4qxmNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
1oc1ASVIsopenicillin N synthase1.21.3.10.445
2gjlFMNNitronate monooxygenase1.13.12.160.445
2hk9NAPShikimate dehydrogenase (NADP(+))/0.445
3hl0NADMaleylacetate reductase/0.445
2nq8ZIDEnoyl-ACP reductase/0.444
4wriOKAOkadaic acid binding protein 2-alpha/0.444
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.443
4q71FADBifunctional protein PutA/0.443
2vcmM11Isopenicillin N synthase1.21.3.10.442
4cdmFO1Deoxyribodipyrimidine photolyase/0.442
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1vzdCB3Thymidylate synthase/0.441
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
3drcMTXDihydrofolate reductase1.5.1.30.440
3t1tGDPProbable gliding protein mglA/0.440
4r20AERCytochrome P450 family 17 polypeptide 2/0.440