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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2aj8SC3Dipeptidyl peptidase 4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2aj8SC3Dipeptidyl peptidase 4/1.000
3ccc7ACDipeptidyl peptidase 4/0.625
4g1f0WGDipeptidyl peptidase 4/0.620
3opmLUIDipeptidyl peptidase 4/0.615
3g0gRUMDipeptidyl peptidase 4/0.592
3g0bT22Dipeptidyl peptidase 4/0.564
2rgu356Dipeptidyl peptidase 4/0.550
3ccbB2YDipeptidyl peptidase 4/0.535
3g0dXIHDipeptidyl peptidase 4/0.534
3qbjNXZDipeptidyl peptidase 4/0.532
3vjlW94Dipeptidyl peptidase 4/0.532
3f8sPF2Dipeptidyl peptidase 4/0.515
3vjkM51Dipeptidyl peptidase 4/0.489
4ffw715Dipeptidyl peptidase 4/0.467
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.461
3q9bB3NAcetylpolyamine amidohydrolase/0.461
2xuoTZ4Acetylcholinesterase3.1.1.70.458
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.454
4q0kGA3Phytohormone-binding protein/0.453
4dyp0MSNucleoprotein/0.452
4qnwFMNChanoclavine-I aldehyde reductase easA/0.450
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
3tr05GPGuanylate kinase/0.448
1vftDCSAlanine racemase/0.447
3h3r14HCollagen type IV alpha-3-binding protein/0.447
2z1mNDPGDP-mannose 4,6-dehydratase/0.445
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.444
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3v0p4GWHisto-blood group ABO system transferase/0.443
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.442
2whqHI6Acetylcholinesterase3.1.1.70.441
4gddNAIUDP-galactopyranose mutase/0.441
1icsFMN12-oxophytodienoate reductase 11.3.1.420.440
2rqfJH3Hemolymph juvenile hormone binding protein/0.440