sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ahr | NAP | Pyrroline-5-carboxylate reductase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 1.000 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.603 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.486 | |
| 1nvm | NAD | Acetaldehyde dehydrogenase | 1.2.1.10 | 0.461 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.460 | |
| 3pef | NAP | Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase | / | 0.460 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.458 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.455 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.453 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.452 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.452 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.451 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.451 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.450 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.448 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.445 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.443 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.443 | |
| 4nwz | FAD | FAD-dependent pyridine nucleotide-disulfide oxidoreductase | / | 0.441 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.441 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.440 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.440 |