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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1yjqNAP2-dehydropantoate 2-reductase1.1.1.169

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1yjqNAP2-dehydropantoate 2-reductase1.1.1.1691.000
1yonA2R2-dehydropantoate 2-reductase1.1.1.1690.720
5hwsNAP2-dehydropantoate 2-reductase/0.573
3hwrNDP2-dehydropantoate 2-reductase/0.531
3wfjNAD2-dehydropantoate 2-reductase/0.496
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.491
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.476
4enhFVXCholesterol 24-hydroxylase/0.471
4ipw1G7Mycocyclosin synthase1.14.21.90.469
4egbNADdTDP-glucose 4,6-dehydratase/0.468
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.467
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.462
2a94AP0L-lactate dehydrogenase1.1.1.270.461
3a1nNADNDP-sugar epimerase/0.460
3hu1AGSTransitional endoplasmic reticulum ATPase3.6.4.60.458
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.456
1bwsNDPGDP-L-fucose synthase/0.455
1dhiMTXDihydrofolate reductase1.5.1.30.455
4q71FADBifunctional protein PutA/0.454
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.453
4xj43ATCyclic GMP-AMP synthase/0.453
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1kkq471Peroxisome proliferator-activated receptor alpha/0.450
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.449
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.449
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.448
1culFOKAdenylate cyclase type 2/0.446
1culFOKAdenylate cyclase type 5/0.446
1ddsMTXDihydrofolate reductase1.5.1.30.446
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.446
1h50FMNPentaerythritol tetranitrate reductase/0.445
1t2cNAIL-lactate dehydrogenase1.1.1.270.445
1yb5NAPQuinone oxidoreductase1.6.5.50.445
2g2zCOZMalonyl CoA-acyl carrier protein transacylase2.3.1.390.445
3mdmFJZCholesterol 24-hydroxylase/0.445
4jia1K3Tyrosine-protein kinase JAK2/0.445
1k6pXN3Gag-Pol polyprotein3.4.23.160.444
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.443
1bw9NADPhenylalanine dehydrogenase/0.442
2eudGCQRibonucleoside-diphosphate reductase large chain 11.17.4.10.442
3ggoNAIPrephenate dehydrogenase/0.442
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
3p62FMNPentaerythritol tetranitrate reductase/0.442
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.442
4zohFADPutative oxidoreductase FAD-binding subunit/0.442
1cjtFOKAdenylate cyclase type 2/0.441
1cjtFOKAdenylate cyclase type 5/0.441
2d8aNADL-threonine 3-dehydrogenase/0.441
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.441
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.441
1dhjMTXDihydrofolate reductase1.5.1.30.440
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.440
2f1kNAPPrephenate dehydrogenase/0.440
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.440