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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1wbpADPSRSF protein kinase 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1wbpADPSRSF protein kinase 12.7.11.11.000
2x7gPVBSRSF protein kinase 22.7.11.10.581
3begANPSRSF protein kinase 12.7.11.10.569
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.501
3le62BZCyclin-dependent kinase 22.7.11.220.484
1finATPCyclin-dependent kinase 22.7.11.220.480
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.468
1aq1STUCyclin-dependent kinase 22.7.11.220.463
2cchATPCyclin-dependent kinase 22.7.11.220.459
4c9pCAMCytochrome P450/0.459
4jr7GNPCasein kinase II subunit alpha2.7.11.10.458
1phgMYTCamphor 5-monooxygenase1.14.15.10.457
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.456
2pvnP63Casein kinase II subunit alpha2.7.11.10.455
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.453
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.453
3r7uX96Cyclin-dependent kinase 22.7.11.220.453
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.451
3tnwF18Cyclin-dependent kinase 22.7.11.220.449
4ihl1F514-3-3 protein zeta/delta/0.448
1iwjCAMCamphor 5-monooxygenase1.14.15.10.447
2zjwREFCasein kinase II subunit alpha2.7.11.10.447
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.447
1nooCAHCamphor 5-monooxygenase1.14.15.10.446
2ovhAS0Progesterone receptor/0.445
3e7iB2Nitric oxide synthase, inducible1.14.13.390.444
4lwbQJ8Nitric oxide synthase oxygenase1.14.13.1650.444
3e6oA55Nitric oxide synthase, inducible1.14.13.390.443
4grb0XGCasein kinase II subunit alpha2.7.11.10.443
3blqATPCyclin-dependent kinase 92.7.11.220.442
1fvv107Cyclin-dependent kinase 22.7.11.220.441
4qnaX11Serine/threonine-protein kinase 242.7.11.10.441
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.440
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.440
3r7iX9ICyclin-dependent kinase 22.7.11.220.440
3s4qNK0Mitogen-activated protein kinase 14/0.440
4enhFVXCholesterol 24-hydroxylase/0.440
4j95ACPFibroblast growth factor receptor 2/0.440
4jia1K3Tyrosine-protein kinase JAK2/0.440