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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1vzqSHYProthrombin3.4.21.5

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1vzqSHYProthrombin3.4.21.51.000
2anmCDOProthrombin3.4.21.50.744
2v3oI26Prothrombin3.4.21.50.709
1ypgUIRProthrombin3.4.21.50.682
1afeALZProthrombin3.4.21.50.674
2zfq45UProthrombin3.4.21.50.671
4ax9N5NProthrombin3.4.21.50.661
1ypeUIPProthrombin3.4.21.50.654
2cn0F25Prothrombin3.4.21.50.651
1ae8AZLProthrombin3.4.21.50.650
1mueCDDProthrombin3.4.21.50.646
1ypjUIBProthrombin3.4.21.50.643
2cf9348Prothrombin3.4.21.50.639
2r2mI50Prothrombin3.4.21.50.639
2zi224UProthrombin3.4.21.50.636
1k21IGNProthrombin3.4.21.50.632
1d4pBPPProthrombin3.4.21.50.631
1d3dBZTProthrombin3.4.21.50.630
3eq02TSProthrombin3.4.21.50.628
2zgx29UProthrombin3.4.21.50.627
7kmeACE_0BN_CHG_PRRProthrombin3.4.21.50.627
1zrb062Prothrombin3.4.21.50.623
2zf051UProthrombin3.4.21.50.619
2zfr46UProthrombin3.4.21.50.617
4ayy9MXProthrombin3.4.21.50.617
2bdyUNBProthrombin3.4.21.50.614
1d6w00RProthrombin3.4.21.50.613
1t4v14AProthrombin3.4.21.50.613
2zhw12UProthrombin3.4.21.50.606
1oytFSNProthrombin3.4.21.50.605
1c4uIH1Prothrombin3.4.21.50.604
1c4yIH3Prothrombin3.4.21.50.604
1d3pBT3Prothrombin3.4.21.50.603
4az29MUProthrombin3.4.21.50.603
1t4u81AProthrombin3.4.21.50.602
3biu10UProthrombin3.4.21.50.601
1mu6CDAProthrombin3.4.21.50.597
2zfp19UProthrombin3.4.21.50.596
2znk31UProthrombin3.4.21.50.595
2v3hI25Prothrombin3.4.21.50.593
4e7r0NWProthrombin3.4.21.50.593
1d9i00PProthrombin3.4.21.50.590
1jwtBLIProthrombin3.4.21.50.588
2zc922UProthrombin3.4.21.50.587
4bakM67Prothrombin3.4.21.50.587
1xm1GAHProthrombin3.4.21.50.584
2zhf49UProthrombin3.4.21.50.584
2zg050UProthrombin3.4.21.50.583
2zgb21UProthrombin3.4.21.50.582
2jh5895Prothrombin3.4.21.50.580
2zhe13UProthrombin3.4.21.50.580
3dux64UProthrombin3.4.21.50.580
1nm6L86Prothrombin3.4.21.50.579
1k22MELProthrombin3.4.21.50.577
2zda32UProthrombin3.4.21.50.577
2bvs2CEProthrombin3.4.21.50.576
1zgv501Prothrombin3.4.21.50.575
2pksG44Prothrombin3.4.21.50.574
4bamMM9Prothrombin3.4.21.50.574
2cf8ESHProthrombin3.4.21.50.573
2jh0701Prothrombin3.4.21.50.572
4n3l2FNProthrombin3.4.21.50.569
1ypkCCRProthrombin3.4.21.50.568
2jh6894Prothrombin3.4.21.50.568
2zdv37UProthrombin3.4.21.50.568
1yplRA8Prothrombin3.4.21.50.567
1z71L17Prothrombin3.4.21.50.566
1sb1165Prothrombin3.4.21.50.565
3c1kT15Prothrombin3.4.21.50.565
1zgi382Prothrombin3.4.21.50.564
1ypmRA4Prothrombin3.4.21.50.563
2zhq27UProthrombin3.4.21.50.563
4lxb7R9Prothrombin3.4.21.50.563
2uuk897Prothrombin3.4.21.50.562
4banM6SProthrombin3.4.21.50.561
2zff53UProthrombin3.4.21.50.559
4baqM4ZProthrombin3.4.21.50.559
1ta6177Prothrombin3.4.21.50.557
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.556
3qwc98PProthrombin3.4.21.50.554
4ayv9MQProthrombin3.4.21.50.550
2gdeSN3Prothrombin3.4.21.50.549
1riwOSCProthrombin3.4.21.50.546
4bahMELProthrombin3.4.21.50.544
1a4wQWEProthrombin3.4.21.50.542
1nzq162Prothrombin3.4.21.50.542
2bxtC2DProthrombin3.4.21.50.534
4baoMVFProthrombin3.4.21.50.534
2uuj896Prothrombin3.4.21.50.533
1w7gMIUProthrombin3.4.21.50.531
3p1799PProthrombin3.4.21.50.531
4rn615UProthrombin3.4.21.50.529
3utu1TSProthrombin3.4.21.50.520
5cmx0G6Prothrombin3.4.21.50.516
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.500
3qto10PProthrombin3.4.21.50.498
3c27DKKProthrombin3.4.21.50.497
3qtv06PProthrombin3.4.21.50.493
1uvsI11Prothrombin3.4.21.50.488
3dhk23UProthrombin3.4.21.50.482
1pqc444Oxysterols receptor LXR-beta/0.481
3biv11UProthrombin3.4.21.50.463
5fm7ADPRuvB-like helicase/0.456
1ghv120Prothrombin3.4.21.50.451
1c4vIH2Prothrombin3.4.21.50.449
2ziq26UProthrombin3.4.21.50.449
2ignFADPyranose 2-oxidase/0.448
4hfp15UProthrombin3.4.21.50.448
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.447
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.446
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.442
4bb3KKAIsopenicillin N synthase1.21.3.10.442
3k4nFADPyranose 2-oxidase/0.441