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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1tvoFRZMitogen-activated protein kinase 12.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1tvoFRZMitogen-activated protein kinase 12.7.11.241.000
4fv9E71Mitogen-activated protein kinase 12.7.11.240.554
4h3qANPMitogen-activated protein kinase 12.7.11.240.539
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.501
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.500
4fuxE75Mitogen-activated protein kinase 12.7.11.240.497
4fv6E57Mitogen-activated protein kinase 12.7.11.240.495
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.494
4b99R4LMitogen-activated protein kinase 72.7.11.240.491
4fmqANPMitogen-activated protein kinase 12.7.11.240.490
4nifANPMitogen-activated protein kinase 12.7.11.240.485
2oji33AMitogen-activated protein kinase 12.7.11.240.482
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.482
2y9qANPMitogen-activated protein kinase 12.7.11.240.479
4s34ANPMitogen-activated protein kinase 12.7.11.240.479
2ojj82AMitogen-activated protein kinase 12.7.11.240.478
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.477
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.476
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.474
4g6oE28Mitogen-activated protein kinase 12.7.11.240.473
3erkSB4Mitogen-activated protein kinase 12.7.11.240.472
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.471
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.470
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.469
3i60E86Mitogen-activated protein kinase 12.7.11.240.466
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.463
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.457
3uvqFS8Mitogen-activated protein kinase 14/0.457
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.456
3qyw6PBMitogen-activated protein kinase 12.7.11.240.456
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.455
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.454
2c4g514Cyclin-dependent kinase 22.7.11.220.454
2ghmLICMitogen-activated protein kinase 14/0.454
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.452
2z7lS91Mitogen-activated protein kinase 12.7.11.240.450
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.450
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.449
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.448
3c4wATPRhodopsin kinase/0.447
2xvdAS6Ephrin type-B receptor 42.7.10.10.446
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.446
4g2fC07Ephrin type-A receptor 32.7.10.10.446
1zrzBI1Protein kinase C iota type2.7.11.130.445
3gc9B45Mitogen-activated protein kinase 112.7.11.240.444
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.444
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4gt3ATPMitogen-activated protein kinase 12.7.11.240.444
1j39UPGDNA beta-glucosyltransferase/0.442
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.442
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.442
4s33ANPMitogen-activated protein kinase 12.7.11.240.441