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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1trgCB3Thymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1trgCB3Thymidylate synthase/1.000
1tysDHFThymidylate synthase/0.663
3bhrTHGThymidylate synthase/0.595
1kceCB3Thymidylate synthase/0.582
1dnaCB3Thymidylate synthase/0.560
2ftoCB3Thymidylate synthase/0.547
2bbqPFGThymidylate synthase/0.532
3bgxMEFThymidylate synthase/0.523
1nceCB3Thymidylate synthase/0.516
4knzCB3Thymidylate synthase/0.514
3bhlTHGThymidylate synthase/0.511
1jtqLY3Thymidylate synthase/0.504
4isk1JYThymidylate synthase/0.503
1jtuLYBThymidylate synthase/0.494
4fqsLYAThymidylate synthase ThyA/0.491
1kzjCB3Thymidylate synthase/0.489
1tduCB3Thymidylate synthase/0.487
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.486
1an5CB3Thymidylate synthase/0.485
4gevCB3Thymidylate synthase/0.481
3uwlFOZThymidylate synthase/0.476
1fwmCB3Thymidylate synthase/0.475
1zprCB3Thymidylate synthase/0.475
1aiqCB3Thymidylate synthase/0.474
1axwMTXThymidylate synthase/0.469
1f4fTP3Thymidylate synthase/0.469
1bq1CB3Thymidylate synthase/0.468
4fogC2FThymidylate synthase ThyA/0.466
1jutLYDThymidylate synthase/0.455
1kziTHGThymidylate synthase/0.453
4foxD16Thymidylate synthase ThyA/0.453
2aazCB3Thymidylate synthase2.1.1.450.452
2tscCB3Thymidylate synthase/0.451
1ju6LYAThymidylate synthase2.1.1.450.446
4o7uTHFThymidylate synthase/0.446
4ez8DHFThymidylate synthase2.1.1.450.444