sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.695 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.692 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.688 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.685 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.683 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.681 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.678 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.677 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.672 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.668 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.668 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.667 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.666 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.659 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.652 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.652 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.650 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.635 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.623 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.622 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.606 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.603 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.601 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.600 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.600 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.539 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.525 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.497 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.491 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.489 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.485 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.482 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.481 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.480 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.479 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.476 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.468 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.467 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.464 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.463 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.461 | |
| 3zuy | TCH | Transporter | / | 0.461 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.459 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.457 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.457 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.455 | |
| 3u9e | COA | Lmo1369 protein | / | 0.455 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.454 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.454 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.454 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.454 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.453 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.453 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.450 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.449 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.448 | |
| 2c6h | PXI | Cytochrome P450 monooxygenase PikC | / | 0.448 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.448 | |
| 2ijg | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.447 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.446 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.445 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.444 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.444 | |
| 4l9q | 9TP | Serum albumin | / | 0.444 | |
| 4zca | ADP | Kinesin-like protein KIF11 | / | 0.444 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.443 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.443 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.443 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.443 | |
| 1bl6 | SB6 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.442 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.442 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 4h6p | FMN | Chromate reductase | / | 0.442 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.441 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.441 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.441 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.440 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.440 |