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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1s1pNAPAldo-keto reductase family 1 member C3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1s1pNAPAldo-keto reductase family 1 member C3/1.000
1s1rNAPAldo-keto reductase family 1 member C3/0.627
4dz5NAPAldo-keto reductase family 1 member C3/0.618
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.609
2hdjNDPAldo-keto reductase family 1 member C2/0.553
4jtqNAPAldo-keto reductase family 1 member C2/0.552
4xo7NAPAldo-keto reductase family 1 member C2/0.549
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.548
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.544
3h7rNAPAldo-keto reductase family 4 member C8/0.535
4l1xNAPAldo-keto reductase family 1 member C2/0.534
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.529
4jq3NAPAldo-keto reductase family 1 member C2/0.528
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.525
2hejNDPAldo-keto reductase family 1 member C211.1.10.516
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.511
2p5nNDPAldo-keto reductase family 1 member C211.1.10.502
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.494
2acqNAPAldose reductase1.1.1.210.485
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.485
1ah4NAPAldose reductase1.1.1.210.483
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.482
3wczNAPAldo-keto reductase AKR2E4/0.480
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.478
2j8tNAPAldose reductase1.1.1.210.476
1x98NAPAldose reductase1.1.1.210.469
4pmjNAPPutative oxidoreductase/0.469
1pz1NAPGeneral stress protein 69/0.463
3v36NAPAldose reductase1.1.1.210.460
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.460
2iq0NAPAldose reductase1.1.1.210.458
3q65NAPAldose reductase1.1.1.210.456
2pf8NDPAldose reductase1.1.1.210.455
3o3rNAPAldose reductase-related protein 11.1.1.210.455
1zgdNAPChalcone reductase/0.452
2he5NDPAldo-keto reductase family 1 member C211.1.10.452
2pevNDPAldose reductase1.1.1.210.452
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.451
1z8aNAPAldose reductase1.1.1.210.451
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.451
1adsNAPAldose reductase1.1.1.210.450
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.450
3q67NAPAldose reductase1.1.1.210.450
1c9wNAPAldose reductase-related protein 2/0.449
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.447
1az2NAPAldose reductase1.1.1.210.446
2clpNDPAflatoxin B1 aldehyde reductase member 3/0.446
1lqaNDPProtein tas/0.445
2acuNAPAldose reductase1.1.1.210.444
4g5dNDPProstaglandin F synthase1.1.1.1880.444
1ef3NAPAldose reductase1.1.1.210.443
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.441
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440