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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1qoqIGPTryptophan synthase alpha chain

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1qoqIGPTryptophan synthase alpha chain/1.000
1kfbIGPTryptophan synthase alpha chain/0.618
1a5bIGPTryptophan synthase alpha chain/0.617
1kfcIPLTryptophan synthase alpha chain/0.615
1k7fIAVTryptophan synthase alpha chain/0.604
2rh9IGPTryptophan synthase alpha chain/0.596
2rhgIGPTryptophan synthase alpha chain/0.589
1beuIPLTryptophan synthase alpha chain/0.550
2cleF6FTryptophan synthase alpha chain/0.522
2clfF6FTryptophan synthase alpha chain/0.495
1k8y13PTryptophan synthase alpha chain/0.487
3oadLPORenin3.4.23.150.472
4y6gF6FTryptophan synthase alpha chain/0.471
3k1wBFXRenin3.4.23.150.463
2cy0NAPShikimate dehydrogenase (NADP(+))/0.459
3g70A5TRenin3.4.23.150.457
4boeCLRJapanin/0.455
1k8zIAGTryptophan synthase alpha chain/0.452
2uxoTACHTH-type transcriptional regulator TtgR/0.452
3ixp834Ecdysone receptor/0.452
1n77ATPGlutamate--tRNA ligase6.1.1.170.451
1g6kNADGlucose 1-dehydrogenase1.1.1.470.450
2gv8NDPThiol-specific monooxygenase1.14.130.448
3g72A6TRenin3.4.23.150.447
1h50FMNPentaerythritol tetranitrate reductase/0.444
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.444
4wx2F6FTryptophan synthase alpha chain/0.444
4wx2F6FTryptophan synthase beta chain4.2.1.200.444
2iyaZIOOleandomycin glycosyltransferase/0.443
2ptfFMNUncharacterized protein MTH_863/0.442
3oagLPQRenin3.4.23.150.442
3slkNDPPolyketide synthase extender module 2/0.442
1m13HYFNuclear receptor subfamily 1 group I member 2/0.441
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.441
4du82P0Mevalonate diphosphate decarboxylase/0.441
3own3OWRenin3.4.23.150.440
4bfwZVWPantothenate kinase2.7.1.330.440