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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1nlyAGSCag alpha

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1nlyAGSCag alpha/1.000
1g6oADPCag alpha/0.501
4d03NAPPhenylacetone monooxygenase1.14.13.920.464
1udbUFGUDP-glucose 4-epimerase5.1.3.20.463
2ylrNAPPhenylacetone monooxygenase1.14.13.920.463
3ai3NDPNADPH-sorbose reductase/0.462
2i7pACOPantothenate kinase 32.7.1.330.460
3ohh3HHBeta-secretase 13.4.23.460.460
4c13UMLUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase/0.455
3gwdNAPCyclohexanone monooxygenase/0.453
4j7xNAPSepiapterin reductase1.1.1.1530.452
4hwkNAPSepiapterin reductase1.1.1.1530.449
1b5eDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.448
4bmvNAPShort-chain dehydrogenase/0.448
3lqfNADGalactitol dehydrogenase/0.446
3tjlFMNNADPH dehydrogenase/0.446
3gkaFMNN-ethylmaleimide reductase/0.444
3mk6ACOPantothenate kinase 32.7.1.330.444
1yreCOAUncharacterized protein/0.443
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.443
4j7uNAPSepiapterin reductase1.1.1.1530.443
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.442
1icpFMN12-oxophytodienoate reductase 11.3.1.420.441
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.441
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.440