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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1m1dLYXHAT A1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1m1dLYXHAT A1/1.000
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
3ggu017Gag-Pol polyprotein3.4.23.160.485
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.471
3livE16Protease/0.470
3el51UNGag-Pol polyprotein/0.469
3qaaG04Gag-Pol polyprotein3.4.23.160.468
1t7j478Gag-Pol polyprotein3.4.23.160.467
3qihNI7Gag-Pol polyprotein3.4.23.160.467
1c70L75Protease/0.466
1sguMK1Gag-Pol polyprotein3.4.23.160.465
1c6zROCProtease/0.463
2i4vDJRV-1 protease/0.463
1bai0Q4Gag-Pro polyprotein/0.461
1sh9RITGag-Pol polyprotein3.4.23.160.461
2uxoTACHTH-type transcriptional regulator TtgR/0.461
3fwjCAMCamphor 5-monooxygenase1.14.15.10.461
1yrdCAMCamphor 5-monooxygenase1.14.15.10.459
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.459
3litE15Protease/0.458
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3t3c017Gag-Pol polyprotein3.4.23.160.457
4mv8ACPBiotin carboxylase6.3.4.140.456
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3zptM8YGag-Pol polyprotein3.4.23.160.453
4a6cQG9Gag-Pol polyprotein3.4.23.160.453
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.453
1msnJE2Gag-Pol polyprotein3.4.23.160.451
1bv9XV6Gag-Pol polyprotein3.4.23.160.450
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
3pwrROCGag-Pol polyprotein3.4.23.160.450
1c6yMK1Protease/0.449
2r43G3GGag-Pol polyprotein3.4.23.160.449
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.449
3el4ROCGag-Pol polyprotein3.4.23.160.449
3so9017Pol protein/0.449
1j7lADPAminoglycoside 3'-phosphotransferase2.7.1.950.448
1rfvADPPyridoxal kinase2.7.1.350.448
2f3kRO1Protease/0.448
2iw94SPCyclin-dependent kinase 22.7.11.220.448
2wl05AHGag-Pol polyprotein/0.448
2avvMK1Gag-Pol polyprotein3.4.23.160.447
4qgiROCGag-Pol polyprotein3.4.23.160.447
1d4yTPVGag-Pol polyprotein3.4.23.160.446
1hncGDNGlutathione S-transferase Mu 22.5.1.180.446
1hsgMK1Gag-Pol polyprotein/0.446
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.446
3lixE17Protease/0.446
4njsG08Protease/0.446
1ida0POGag-Pol polyprotein3.4.23.470.445
3ekx1UNGag-Pol polyprotein3.4.23.160.445
3jvy017Gag-Pol polyprotein3.4.23.160.445
3zpuM8BGag-Pol polyprotein3.4.23.160.445
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.445
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.444
3rvhHQ2Lysine-specific demethylase 4A1.14.110.444
3zewSTUEphrin type-B receptor 42.7.10.10.444
4ryvZEAProtein LlR18A/0.444
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2c6o4SPCyclin-dependent kinase 22.7.11.220.443
2iw84SPCyclin-dependent kinase 22.7.11.220.443
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.443
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.443
3fr8NDPKetol-acid reductoisomerase, chloroplastic1.1.1.860.443
3tz3B36Acetyl-CoA carboxylase/0.443
1jld0PPGag-Pol polyprotein/0.442
1t86CAMCamphor 5-monooxygenase1.14.15.10.442
2bpy3INGag-Pol polyprotein3.4.23.160.442
2y9qANPMitogen-activated protein kinase 12.7.11.240.442
2zaxCAMCamphor 5-monooxygenase1.14.15.10.442
3bgcLJHGag-Pol polyprotein3.4.23.160.442
3bxsDRSGag-Pol polyprotein3.4.23.160.442
3el1DR7Gag-Pol polyprotein3.4.23.160.442
4a6bQG8Gag-Pol polyprotein3.4.23.160.442
1b6kPI5Gag-Pol polyprotein3.4.23.160.441
1bdrIM1Gag-Pol polyprotein3.4.23.160.441
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.441
2cen4AHProtease/0.441
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.441
4otiMI1Serine/threonine-protein kinase N1/0.441
4xgxADPFAD:protein FMN transferase/0.441
2fdd385Pol protein/0.440
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2p3a3TLPol protein/0.440
2r3wG3GGag-Pol polyprotein3.4.23.160.440
3ddpRC8Cyclin-dependent kinase 22.7.11.220.440
4i13FOLDihydrofolate reductase1.5.1.30.440